Keith R. Jerome is an American virologist whose research focuses on viruses such as herpes simplex, HIV and hepatitis B that persist in their hosts. He published on the first known case of COVID-19 in the United States detecting SARS-CoV-2 in Washington State[1] and helped forge the nation's COVID-19 testing.[2][3][4] In 2021, Jerome and Alexander Greninger shared the Washington Innovator of the Year award for developing the laboratory based assay for detecting COVID-19.[5] He was senior author on a research article published in Science describing the cryptic transmission of SARS-CoV-2 alongside Trevor Bedford, Alexander Greninger, Jay Shendure, and Helen Chu.[6] Regarding the origin of SARS-CoV-2 he reported that the live market in Wuhan was more likely than a lab leak of the virus.[7]

Jerome studies the ways in which these viruses evade the immune system and potential therapies for these infections. Jerome and his colleagues study the uses of precision gene-editing tools like CRISPR/Cas9 to remove damaging viral genes that have tucked themselves into a person's genetic code or to insert genes that can protect cells from invading viruses. He has been working for years on research aimed at a cure for Herpes virus by using the DNA-cutting tools of gene therapy. Initial research showed these techniques could knock out small quantities of latent virus.[8] He and his colleagues are exploring this approach in combination with blood stem cell transplants as a means of curing HIV.

Academic and medical appointments

  • Full professor, Fred Hutchinson Cancer Research Center, 2015–present
  • Head, Virology Division, Laboratory Medicine, University of Washington, 2012–present
  • Professor, Department of Laboratory Medicine and Pathology, University of Washington, 2012–present

Education and training

  • Senior Fellow, Virology Division, Department of Laboratory Medicine, University of Washington, 1997-1998
  • Resident Physician, Department of Laboratory Medicine, University of Washington, 1995-1997
  • Resident Physician, Department of Pathology, University of Washington, 1993-1995
  • Duke University, MD, May 1993
  • Duke University, PhD, Microbiology and Immunology, 1992
  • Georgetown College, B.S., Chemistry, summa cum laude, 1985

Selected publications

References

  1. ↑ Bhatraju, Pavan K.; Ghassemieh, Bijan J.; Nichols, Michelle; Kim, Richard; Jerome, Keith R.; Nalla, Arun K.; Greninger, Alexander L.; Pipavath, Sudhakar; Wurfel, Mark M.; Evans, Laura; Kritek, Patricia A.; West, T. Eoin; Luks, Andrew; Gerbino, Anthony; Dale, Chris R.; Goldman, Jason D.; O'Mahony, Shane; Mikacenic, Carmen (May 21, 2020). "Covid-19 in Critically Ill Patients in the Seattle Region - Case Series". The New England Journal of Medicine. 382 (21): 2012–2022. doi:10.1056/NEJMoa2004500. PMC 7143164. PMID 32227758.
  2. ↑ "How UW's Virology Lab Helped Forge the Nation's Covid-19 Testing". Seattle Met.
  3. ↑ "When Coronavirus Struck Seattle, This Lab Was Ready To Start Testing". NPR.
  4. ↑ Maxmen, Amy (March 6, 2020). "The race to unravel the biggest coronavirus outbreak in the United States". Nature. 579 (7798): 181–182. Bibcode:2020Natur.579..181M. doi:10.1038/d41586-020-00676-3. PMID 32152595. S2CID 212655031.
  5. ↑ "Innovator of the Year awarded to directors of virology lab". newsroom.uw.edu. April 28, 2021.
  6. ↑ Bedford, Trevor; Greninger, Alexander L.; Roychoudhury, Pavitra; Starita, Lea M.; Famulare, Michael; Huang, Meei-Li; Nalla, Arun; Pepper, Gregory; Reinhardt, Adam; Xie, Hong; Shrestha, Lasata; Nguyen, Truong N.; Adler, Amanda; Brandstetter, Elisabeth; Cho, Shari; Giroux, Danielle; Han, Peter D.; Fay, Kairsten; Frazar, Chris D.; Ilcisin, Misja; Lacombe, Kirsten; Lee, Jover; Kiavand, Anahita; Richardson, Matthew; Sibley, Thomas R.; Truong, Melissa; Wolf, Caitlin R.; Nickerson, Deborah A.; Rieder, Mark J.; Englund, Janet A.; Hadfield, James; Hodcroft, Emma B.; Huddleston, John; Moncla, Louise H.; Müller, Nicola F.; Neher, Richard A.; Deng, Xianding; Gu, Wei; Federman, Scot; Chiu, Charles; Duchin, Jeffrey S.; Gautom, Romesh; Melly, Geoff; Hiatt, Brian; Dykema, Philip; Lindquist, Scott; Queen, Krista; Tao, Ying; Uehara, Anna; Tong, Suxiang; MacCannell, Duncan; Armstrong, Gregory L.; Baird, Geoffrey S.; Chu, Helen Y.; Shendure, Jay; Jerome, Keith R. (October 30, 2020). "Cryptic transmission of SARS-CoV-2 in Washington state". Science. 370 (6516): 571–575. doi:10.1126/science.abc0523. PMC 7810035. PMID 32913002.
  7. ↑ "UW Medicine's head of Virology: Live market 'more likely the start' of COVID". MyNorthwest.com. November 28, 2021.
  8. ↑ Russell, Sabin (2020-08-18). "A cure for herpes? There is progress to report". Fred Hutch. Retrieved 2022-04-03.
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