Kupe orthonairovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Nairoviridae
Genus: Orthonairovirus
Species:
Kupe orthonairovirus

Kupe orthonairovirus, also called Kupe virus, is a species of virus in the genus Orthonairovirus.[1]

History

The virus was isolated from pooled ticks (Amblyomma gemma and Rhipicephalus pulchellus) collected from cattle hides in Nairobi, Kenya, in October 1999.[2] The word 'Kupe' is Kiswahili for tick.

Genome

The genome is composed a single strand of negative sense RNA in three parts - small (S), medium (M0 and large(L).

The L segment RNA is 12,330 nucleotides (nt) in length and encodes one open reading frame (ORF) of 4,050 amino acids. There is a non coding regions: the 5′ region of 40 nt and the 3′ region of 137 nt. This open reading frame encodes several modules including a RNA-dependent RNA polymerase. It is probably post translationally cleaved into several proteins but this has yet to be shown.

The M segment RNA is 4,818 nucleotides in length and contains one open reading frame flanked by 5′ and 3′ non coding regions of 47 and 121 nucleotides respectively. The ORF encodes a protein of 1549 amino acids with 8 potential sites for N-linked glycosylation. It contains a unique potential N-gly site in the Gn and Gc glycoprotein regions at amino acids 612 and 1514 respectively.

The S segment has 1,694 nt and encodes an ORF of 483 amino acids. The 5′ and 3′ noncoding regions are 49 nt and 193 nt in length respectively.

References

  1. ↑ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 25 May 2021.
  2. ↑ Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B (2006) Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya. Emerg Infect Dis. 2006 Jul;12(7):1074-1080
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