LEFTY1
Identifiers
AliasesLEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDsOMIM: 603037 MGI: 107405 HomoloGene: 49231 GeneCards: LEFTY1
Orthologs
SpeciesHumanMouse
Entrez

10637

13590

Ensembl

ENSG00000243709

ENSMUSG00000038793

UniProt

O75610

Q64280

RefSeq (mRNA)

NM_020997

NM_010094

RefSeq (protein)

NP_066277

NP_034224

Location (UCSC)Chr 1: 225.89 – 225.91 MbChr 1: 180.76 – 180.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene. [5]

Function

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Left-right determination factor 1". Retrieved 2016-08-03.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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