LIMS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLIMS2, PINCH-2, PINCH2, LGMD2W, LIM zinc finger domain containing 2, MDRCMTT
External IDsOMIM: 607908 MGI: 2385067 HomoloGene: 41214 GeneCards: LIMS2
Orthologs
SpeciesHumanMouse
Entrez

55679

225341

Ensembl

ENSG00000072163

ENSMUSG00000024395

UniProt

Q7Z4I7

Q91XD2

RefSeq (mRNA)

NM_001136037
NM_001161403
NM_001161404
NM_001256542
NM_017980

NM_144862
NM_001365015
NM_001379137
NM_001379138

RefSeq (protein)

NP_001129509
NP_001154875
NP_001154876
NP_001243471
NP_060450

NP_659111
NP_001351944
NP_001366066
NP_001366067

Location (UCSC)Chr 2: 127.64 – 127.68 MbChr 18: 32.06 – 32.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene. [5]

Function

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000072163 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024395 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: LIM zinc finger domain containing 2". Retrieved 2017-11-06.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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