Ligustilide
Names
Other names
3-Butylidene-4,5-dihydrophthalide
Identifiers
3D model (JSmol)
ECHA InfoCard 100.237.128
  • O=C1OC(=CCCC)C2=C1C=CCC2
Properties
C12H14O2
Molar mass 190.242 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Ligustilide is a natural chemical compound of the dihydrophthalide class. Ligustilide is found in the highest concentration in wild celeries (Apium graveolens).[1][2] It has also been found in Angelica sinensis and a variety of other plants including Todaroa montana.[2]

Potential pharmacology

Because of the traditional use of Angelica sinesis in herbal medicine, particularly traditional Chinese medicine where it is known as dong quai, there has been interest in identifying chemical compounds responsible for its putative pharmacological effects. Ligustilide is typically identified as the principal bioactive component.[3] A variety of in vitro effects of ligustilide have been reported, including antiinflammatory and neuroprotective effects.[4] However, because of the chemical instability of ligustilide, the relevance of these studies to any effects in humans is uncertain.[5]

References

  1. ↑ "Ligustilide". Human Metabolome Database.
  2. 1 2 Gijbels, M.J.M., Fischer, F.C., Scheffer, J.J.C.; et al. (1983). "Phthalides in roots of Anethum graveolens and Todaroa montana". Scientia Pharmaceutica. 51 (4): 414–417.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ↑ Yang, F.; Lin, Z. W.; Huang, T. Y.; Chen, T. T.; Cui, J.; Li, M. Y.; Hua, Y. Q. (2019). "Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway". Scientific Reports. 9 (1): 6991. Bibcode:2019NatSR...9.6991Y. doi:10.1038/s41598-019-43518-7. PMC 6502875. PMID 31061445.
  4. ↑ Xie, Qingxuan; Zhang, Linlin; Xie, Long; Zheng, Yu; Liu, Kai; Tang, Hailong; Liao, Yanmei; Li, Xiaofang (2020). "Z‐ligustilide: A review of its pharmacokinetics and pharmacology". Phytotherapy Research. 34 (8): 1966–1991. doi:10.1002/ptr.6662. PMID 32135035. S2CID 212567563.
  5. ↑ Duric, Kemal; Liu, Yang; Chen, Shao-Nong; Lankin, David C.; Nikolic, Dejan; McAlpine, James B.; Friesen, J. Brent; Pauli, Guido F. (2019). "Studying Mass Balance and the Stability of (Z)-Ligustilide from Angelica sinensis Helps to Bridge a Botanical Instability–Bioactivity Chasm". Journal of Natural Products. 82 (9): 2400–2408. doi:10.1021/acs.jnatprod.8b00962. PMC 6930006. PMID 31478376.
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