The first sequences of keratins revealed that keratins could be grouped into two categories based on their sequence homologies.[1][2] These two groups of keratins were named as type I and type II keratins.[2] These two categories also represent the first two categories of the superfamily of intermediate filament proteins.

Keratins in this table are classified in the first two columns according to the nomenclature established in 2006.[3] Other names previously used are listed in columns 3 and 4.

Type I keratins

Human epithelial keratins

Protein name[3]Gene name[3]Other protein nameOther gene name
K9KRT9Ka9
K10KRT10Ka10
K12KRT12Ka12
K13KRT13Ka13
K14KRT14Ka14
K15KRT15Ka15
K16KRT16Ka16
K17KRT17Ka17
K18KRT18Ka18
K19KRT19Ka19
K20KRT20Ka20
K23KRT23Ka23
K24KRT24Ka24
K25KRT25Ka38, K25irs1, K10C, hIRSa1KRT25A
K26KRT26Ka39, K25irs2, K10D
K27KRT27Ka40, K25irs3, K10B, hIRSa3.1
K28KRT28Ka41, K25irs4, hIRSa2

Human hair keratins

Protein name[3]Gene name[3]Other protein nameOther gene name
K31KRT31Ka25, Ha1KRTHA1
K32KRT32Ka26, Ha2KRTHA2
K33aKRT33AKa27, Ha3-IKRTHA3A
K33bKRT33BKa28, Ha3-IIKRTHA3B
K34KRT34Ka29, Ha4KRTHA4
K35KRT35Ka30, Ha5KRTHA5
K36KRT36Ka31, Ha6KRTHA6
K37KRT37Ka32, Ha7KRTHA7
K38KRT38Ka33, Ha8KRTHA8
K39KRT39Ka35
K40KRT40Ka36

Nonhuman hair/epithelial keratins

Protein name[3]Gene name[3]Other protein nameOther gene name
K41 chimp, gorilla, dog[4]KRT41 chimp, gorilla, dog; KRT41P man, horseφhHaA, Ka34P man
K42 mouse, ratKRT42 mouse, rat; KRT42P manKa22 mouse, rat, K17n mouse, rat

Human keratin pseudogenes

Protein name[3]Gene name[3]Other protein nameOther gene name
KRT221PφhHaB
KRT222PφKRTI, Ka21P
KRT223PφKRTJ, Ka37P

Type II keratins

Human epithelial keratin

Protein name[3]Gene name[3]Other protein nameOther gene name
K1KRT1Kb1
K2KRT2Kb2, K2eKRT2A
K3KRT3Kb3
K4KRT4Kb4
K5KRT5Kb5
K6aKRT6AKb6
K6bKRT6BKb10
K7KRT7Kb7
K8KRT8Kb8
K71KRT71Kb34, K6irs1
K72KRT72Kb35, K6irs2
K73KRT73Kb36, K6irs3
K74KRT74Kb37, K6irs4
K75KRT75Kb18, K6hf
K76KRT76Kb9, K2pKRT2B
K77KRT77Kb39, K1b
K78KRT78Kb40, K5b
K79KRT79Kb38, K6I
K80KRT80Kb20

Human hair keratins

Protein name[3]Gene name[3]Other protein nameOther gene name
K81KRT81Kb21, Hb1, K2.9KRTHB1
K82KRT82Kb22, Hb2KRTHB2
K83KRT83Kb23, Hb3, K2.10KRTHB3
K84KRT84Kb24, Hb4KRTHB4
K85KRT85Kb25, Hb5, K2.12KRTHB5
K86KRT86Kb26, Hb6, K2.11KRTHB6

Human keratin pseudogenes

Protein name[3]Gene name[3]Other protein nameOther gene name
KRT121PφhHbD, Kb31P
KRT122PφhHbC, Kb30P
KRT123PφhHbB, Kb29P
KRT124PφhHbA, Kb28P
KRT125PφKRTH
KRT126PφKRTG, Kb19P
KRT127PφKRTF
KRT128PφKRTE

See also

References

  1. ↑ Hanukoglu, I.; Fuchs, E. (Nov 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–52. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. S2CID 35796315.
  2. 1 2 Hanukoglu, I.; Fuchs, E. (Jul 1983). "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins". Cell. 33 (3): 915–24. doi:10.1016/0092-8674(83)90034-X. PMID 6191871. S2CID 21490380.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Schweizer J, Bowden PE, Coulombe PA, et al. (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  4. ↑ Balmer, P; Bauer, A; Pujar, S; McGarvey, KM; Welle, M; Galichet, A; Müller, EJ; Pruitt, KD; Leeb, T; Jagannathan, V (2017). "A curated catalog of canine and equine keratin genes". PLOS ONE. 12 (8): e0180359. Bibcode:2017PLoSO..1280359B. doi:10.1371/journal.pone.0180359. PMC 5573215. PMID 28846680.
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