Luigi Naldini (born 1959 in Turin) is an Italian gene therapist, professor of cell and tissue biology and of gene and cell therapy at Vita-Salute San Raffaele University, and the director of San Raffaele Telethon Institute for Gene Therapy in Milan, Italy. Often considered as "the father of the lentivirus gene therapy",[1] he is globally known as the pioneer of "the development and applications of lentiviral vectors for gene transfer" that allowed the gene therapy treatment of several genetic diseases.[2][3][4] He is also a scientific co-founder of three biotech start-up companies, Genenta in Milan and New York,[1] Chroma Medicine in Milan and Boston,[3] Genespire in Milan.[5][6] He is also the former president of European Society of Gene and Cell Therapy (ESGCT)[7] and an elected member of European Molecular Biology Organization (EMBO).[6] In 2019, he was awarded Louis-Jeantet Prize for Medicine "for taking gene therapy from the bench to the bedside".[8]

Education and career

He graduated in 1983 with an M.D. from the University of Turin and in 1987 with a Ph.D. in cell and tissue biology from the Sapienza University of Rome. His doctoral advisor was Paolo M. Comoglio. As a postdoc from 1987 to 1989, Naldini was supervised by Joseph Schlessinger in Rockville, Maryland. From 1990 to 1996 Naldini was an assistant professor in the University of Turin's department of biomedical sciences and oncology.[2] From 1994 to 1996 he was a visiting scientist at the Salk Institute in La Jolla, California. From 1996 to 1998 Naldini worked in biotechnology in Foster City, California as a visiting scientist and director at Cell Genesys (which was taken over by BioSante Pharmaceuticals in 2009). From 1998 to 2002 he was an associate professor at the University of Turin's Medical School. At the Vita-Salute San Raffaele University's School of Medicine, he is since 2003 a full professor of cell and tissue biology. At Milan's San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), he was from 2003 to 2008 the co-director and is since 2008 the director.[2] Over the last 25 years, he has made significant contribution to the field of gene therapy, from its development to its huge application in the clinic.[9][10][6] His research also advanced the "use of artificial nucleases for targeted genome editing in cell and gene therapy."[2] He also serves the Committee on Human Genome Editing of three national academies of United States, National Academy of Sciences, National Academy of Engineering, and National Academy of Medicine.[11]

Awards and accolades

References

  1. 1 2 https://www.genenta.com/leadership/
  2. 1 2 3 4 "Luigi Naldini". Università Vita-Salute San Raffaele (hsr.it).
  3. 1 2 https://chromamedicine.com/team/?term=founders
  4. https://research.hsr.it/en/news/the-2019-louis-jeantet-prize-awarded-to-luigi-naldini.html#:~:text=Luigi%20Naldini%2C%20director%20of%20the,bedside%2C%20allowing%20to%20treat%20several
  5. https://www.genespire.com/en/about-us/founders/
  6. 1 2 3 4 5 6 7 https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy/gene-transfer-technologies-and-new-gene-therapy-strategies/luigi-naldini.html
  7. 1 2 https://www.esgct.eu/post/2015-awards-winners
  8. https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2019-en/
  9. 1 2 3 https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2019-en/luigi-naldini/
  10. https://www.thefutureofscience.org/speakerdetail/sixth-world-conference-on-the-future-of-science-viruses-the-invisible-enemy-naldini-luigi-295
  11. https://www.ncbi.nlm.nih.gov/books/NBK447259/
  12. https://www.telethon.it/cosa-facciamo/ricerca/ricercatori/luigi-naldini
  13. https://www.lincei.it/it/content/naldini-luigi
  14. https://www.eyeofriyadh.com/news/details/inaugural-global-health-pioneer-awards-launched-in-dubai
  15. http://tradearabia.com/news/HEAL_350282.html
  16. http://wam.ae/en/details/1395302735400
  17. https://www.hematology.org/awards/honorific/ernest-beutler-lecture-prize-recipients
  18. https://www.fondazionesanraffaele.it/news/assegnato-al-prof-naldini-il-premio-capitani-dellanno-2016/
  19. https://www.telethon.it/storie-e-news/news/dalla-fondazione/a-luigi-naldini-il-jimenez-diaz-prize-2016/
  20. https://www.fundacionconchitarabago.net/lecci%C3%B3n-conmemorativa
  21. https://www.unisr.it/en/docenti/n/naldini-luigi
  22. https://www.ncbi.nlm.nih.gov/books/NBK447272/
  23. https://www.accademiadellescienze.it/premio-Gili-Agostinelli
  24. https://asgct.org/membership/grants-awards/outstanding-achievement-award
  25. https://people.embo.org/profile/luigi-naldini
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