MAP4K1
Identifiers
AliasesMAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
External IDsOMIM: 601983 MGI: 1346882 HomoloGene: 5199 GeneCards: MAP4K1
Orthologs
SpeciesHumanMouse
Entrez

11184

26411

Ensembl

ENSG00000282928
ENSG00000104814

ENSMUSG00000037337

UniProt

Q92918

P70218

RefSeq (mRNA)

NM_001042600
NM_007181

NM_008279
NM_001355054

RefSeq (protein)

NP_001036065
NP_009112

NP_032305
NP_001341983

Location (UCSC)Chr 19: 38.59 – 38.62 MbChr 7: 28.68 – 28.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.[5] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.[6]

Interactions

MAP4K1 has been shown to interact with:

References

  1. 1 2 3 ENSG00000104814 GRCh38: Ensembl release 89: ENSG00000282928, ENSG00000104814 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037337 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
  6. ↑ Chuang HC, Wang X, Tan TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advances in Immunology. Vol. 129. pp. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996. PMID 26791862. {{cite book}}: |journal= ignored (help)
  7. ↑ Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. doi:10.1084/jem.194.4.529. PMC 2193495. PMID 11514608.
  8. 1 2 3 Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432. S2CID 19885101.
  9. 1 2 3 4 Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. doi:10.1128/MCB.19.2.1359. PMC 116064. PMID 9891069.
  10. 1 2 3 4 5 Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
  11. ↑ Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
  12. ↑ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918. S2CID 25646725.
  13. 1 2 Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. PMID 9346925.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.