MAM domain containing glycosylphosphatidylinositol anchor 2
Identifiers
SymbolMDGA2
Alt. symbolsMAMDC1
NCBI gene161357
HGNC19835
OMIM611128
RefSeqNM_182830
Other data
LocusChr. 14 q21.2

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]

There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]

References

  1. "MDGA2 Gene GeneCards". Weizmann Institute of Science. 2008-09-08.
  2. "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.
  3. Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943. S2CID 25186151.
  4. "SNP linked to Gene MDGA2". NCBI.
  5. van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D (September 2008). "18762592". Archives of General Psychiatry. 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.
  6. Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning (2009). "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892. PMID 19440164.
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