MFSD5
Identifiers
AliasesMFSD5, hsMOT2, major facilitator superfamily domain containing 5, SLC61A1
External IDsMGI: 2145901 HomoloGene: 69517 GeneCards: MFSD5
Orthologs
SpeciesHumanMouse
Entrez

84975

106073

Ensembl

ENSG00000182544

ENSMUSG00000045665

UniProt

Q6N075

Q921Y4

RefSeq (mRNA)

NM_001170790
NM_032889

NM_134100

RefSeq (protein)

NP_001164261
NP_116278

NP_598861

Location (UCSC)Chr 12: 53.25 – 53.25 MbChr 15: 102.19 – 102.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane.[5] It is a plausible Solute carrier transporter.[6] It transports molybdate anions,[7] and it interacts with GLP-1R.[8]

MFSD5 belongs to AMTF6.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182544 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045665 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  6. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.
  8. Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.
  9. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
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