MIR1269A
Identifiers
Aliases	MIR1269A, MIR1269, MIRN1269, hsa-mir-1269, hsa-mir-1269a, microRNA 1269a
External IDs	GeneCards: MIR1269A
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 66,276,824 bp[1] End 66,276,928 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gastrocnemius muscle blood thoracic aorta ascending aorta subcutaneous adipose tissue dorsolateral prefrontal cortex nucleus accumbens skin of abdomen tibial nerve n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100302177 n/a Ensembl ENSG00000221563 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 4: 66.28 – 66.28 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

MicroRNA 1269a is a protein that in humans is encoded by the MIR1269A gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.