MIRLET7F2
Identifiers
AliasesMIRLET7F2, LET7F2, MIRNLET7F2, let-7f-2, microRNA let-7f-2
External IDsOMIM: 300721 GeneCards: MIRLET7F2
Orthologs
SpeciesHumanMouse
Entrez

406889

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Ensembl

ENSG00000208012

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UniProt

n
a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)Chr X: 53.56 – 53.56 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

MicroRNA let-7f-2 is a protein that in humans is encoded by the MIRLET7F2 gene. [3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000208012 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Entrez Gene: MicroRNA let-7f-2". Retrieved 2017-11-07.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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