MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA. It is believed to be involved in skeletal muscle and glucose metabolism. It is upregulated in response to exercise, and is considered an exercise mimetic.[1][2]

MOTS-c binds to casein kinase 2.[3]

Society and culture

Researchers discovered MOTS-c in 2015.[4]

MOTS-c is not approved to treat any medical condition and is banned by the World Anti-Doping Agency, explicitly beginning in 2024.[5]

References

  1. ↑ Lee, Changhan; Kim, Kyung Hwa; Cohen, Pinchas (1 November 2016). "MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism". Free Radical Biology and Medicine. 100: 182–187. doi:10.1016/j.freeradbiomed.2016.05.015. ISSN 0891-5849. PMC 5116416. PMID 27216708.
  2. ↑ Dieli-Conwright, Christina M.; Sami, Nathalie; Norris, Mary K.; Wan, Junxiang; Kumagai, Hiroshi; Kim, Su-Jeong; Cohen, Pinchas (19 August 2021). "Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors". Scientific Reports. 11 (1): 16916. Bibcode:2021NatSR..1116916D. doi:10.1038/s41598-021-96419-z. ISSN 2045-2322. PMC 8376922. PMID 34413391.
  3. ↑ Kumagai, Hiroshi; Kim, Su-Jeong; Miller, Brendan; Natsume, Toshiharu; Lee, Shin Hyung; Sato, Ayaka; Ramirez, Ricardo; Wan, Junxiang; Mehta, Hemal H; Yen, Kelvin; Cohen, Pinchas (May 2023). "Casein kinase 2 is a direct binding partner and a functional target of the exercise-mimetic microprotein MOTS-c". Physiology. 38 (S1). doi:10.1152/physiol.2023.38.S1.5725846. ISSN 1548-9213. S2CID 258979715.
  4. ↑ Wan, Wei; Zhang, Lieliang; Lin, Yue; Rao, Xiuqing; Wang, Xifeng; Hua, Fuzhou; Ying, Jun (2023). "Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging". Journal of Translational Medicine. 21 (1): 36. doi:10.1186/s12967-023-03885-2. PMC 9854231. PMID 36670507.
  5. ↑ "Explanation of Key Changes on the 2024 WADA Prohibited List". 13 October 2023. Retrieved 6 December 2023.
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