1985–2002

After the completion of her music studies, she signed her first record contract with CBS, which gave her the international hit "Fill me up" and offered her the chance of an international career at a very young age. Mando remained in America for five years where she took up vocal training with Hal Sheaffer (vocal trainer of Barbra Streisand and Liza Minnelli) and interacted with many musicians, producers and with people who helped her talent grow. Her diverse knowledge and international edge defined her as the Greek artist with the international voice. Vangelis Yannopoulos, an A&R manager with record company Minos EMI heard of all these assets and signed Mando for her first album with the company that she stayed with for six successful albums: Dos mou ena fili... Afto to kalokeri" (Give me a kiss... This summer), "Ptisi gia dio" (Flight for two), "Kinisi triti" (Third move), "Esthisis" (Senses), "I diki mas I agapi" (Our love), and "Anisiho vlema" (Uneasy look).

She has released four albums under the Sony label: "Ston evdomo ourano" (On the seventh sky), "Gia oles tis fores" (For all the times), "Prodosia" (Betrayal), "Se alli Diastasi" (In another dimension). She also released three CD singles under this label. Mando's hits include "Danika" (Borrowed), "Faros" (Lighthouse), "Ston evdomo ourano" (On the seventh sky), "Esi" (You), "Fotia sta prepi" (Burn the have to's).

Her international tours have included cities such as Los Angeles, London, Paris, Toronto, Montreal, New York, and Chicago.

She has toured and collaborated with many established artists such as: Marinella, D. Mitropanos, Tolis Voskopoulos, Paschalis Terzis, C. Nikolopoulos, Dimitra Galani.

Mando has collaborated with the best songwriters in the Greek music business, such as Phoivos, A. Papadimitriou, K. Haritodiplomenos, N. Germanou, G. Theofanous, E. Giannatsoulia. Several of Mando's compositions have been sung by artists such as P. Terzis and K. Kouka.

Mando composes mainly on her guitar. She penned the track "Where You Are" for Jessica Simpson; it has been chosen as the theme song to 20th century Fox's film production titled "Here on Earth". It has sold more than one million copies.

An international collaboration is that with Jean Michel Jarre on one of his own tracks and sung by Mando in Greek with the title "Zoi" (Life); it will be included on her new album.

Another international collaboration is Mando's duet with Turkish top artist Sertab Erener, titled "Aşk/Fos" (Love/Light).

At the end of 2003, Mando recorded a new double album with Alpha records called Oi agapes fevgoun, ta tragoudia menoun (The loves are gone by, the songs remain).

2003: Eurovision

Mando's first attempt to enter the Eurovision Song Contest was in 1989; she was second, only one point behind Marianna. She took action against the Greek television station ERT because one of the jury members didn't vote. She won the ruling, but because it was too late to reverse the decision, Marianna went to Eurovision.

Mando was chosen to represent Greece at the Eurovision Song Contest 2003 with the song "Never Let You Go". She was placed 17th.^[3]

2008: Mando II and Afraid of the Dark

Mando planned a comeback for 2008 with two new albums: one Greek and one English. The first single from the Greek album titled "Dos Mou Logo Na Sotho" (" Δως Μου Λόγο Να Σωθώ ") is a rock song and was released as a music video on 10 May 2008, premiering on "Megastar". The album, titled Mando II, was released on 30 May 2008 with twelve new tracks.

The English album, provisionally titled Afraid of the Dark, has evident American beats and is a very promising international album for Mando. Four songs from the album were released by means of her official Myspace and the album was expected to be released sometime in 2009 but it was cancelled.

2011–2013: Phoebus 20 years, Shamone and Your face Sounds Familiar

In September 2011 her album Perfection was released from Polymusic. Tha se Perimenw (I'll be waiting for you), Mia Signomi ti na kanei (Sorry is not Enough) and Theos pano sti gi (God in earth) are some of more popular songs of this album.

On 24 September 2012, Mando participated in a special 20-year Anniversary concert dedicated to Phoebus. The concert took place at the Olympic Stadium in Athens where the 2004 Summer Olympics were held.^[4] Mando sang her songs "Gia Oles Tis Fores" and "Daneika" along with "Emeis", a duet between her and Antonis Remos which are all songs written by Phoebus.^[5]

On 2 December, she appeared at Shamone, a night bar-club where she sang a lot of her songs and international songs such as Adele's Skyfall, Nina Simone's I Put a Spell on You and Madonna's Frozen. On 21 January 2013 she appeared at Half Note Jazz Club, where she sang a tribute to her singer and mentor Stevie Wonder.

The performance of Stevie Wonder which aired second of June was her biggest success on this TV show where she one first place in that episode.

During this season she gave many interviews in several Greek Late Night Shows like Ola with Themos Anastasiadis and Vrady with Petros Kostopoulos, and early-morning shows like Kalimera Ellada with Giorgos Papadakis and Fthistv with Thanasis Patras which all was aired by Ant1.

2014–15

She participated as a special guest star at the semi-final of The Voice of Greece where she sang her new song "Poliploka" from her upcoming album.