Empress

At the end of 1159, Manuel's wife Empress Irene (originally named Bertha of Sulzbach) had died, and Manuel wanted to marry a princess from one of the Crusader states. John Kontostephanos, the chief dragoman (interpreter) Theophylact, and the akolouthos of the Varangian Guard Basil Kamateros were sent to Jerusalem to seek a new wife, and the two princesses Maria of Antioch and Melisende of Tripoli, a daughter of Count Raymond II of Tripoli by Hodierna of Jerusalem, were offered as candidates. Both were renowned for their beauty, but according to John Kinnamos Maria was the more beautiful of the two; the tall, blonde-haired princess clearly showed her Norman ancestry. King Baldwin III suggested Melisende, and her brother Count Raymond III of Tripoli set about gathering an enormous dowry, with gifts from Hodierna and from Melisende's namesake, her aunt Queen Melisende. The ambassadors were not satisfied and delayed the marriage for over a year; they had apparently heard rumours concerning Hodierna's infidelity and therefore Melisende's possible legitimacy. Instead, Manuel chose Maria. Count Raymond was insulted and in retaliation attacked Byzantine Cyprus.

Meanwhile, an imperial embassy led by Alexios Bryennios Komnenos and the prefect of Constantinople, John Kamateros, came to Antioch to negotiate the marriage. Maria embarked from the port of St. Simeon for Constantinople in September 1161, and the marriage took place in Hagia Sophia on December 24. Three patriarchs performed the marriage: Luke Chrysoberges, Patriarch of Constantinople; Sophronios, Greek Patriarch of Alexandria, and Athanasios I, Greek Patriarch of Antioch. The marriage was celebrated with feasts, gifts to the church, and chariot races in the Hippodrome for the people. This strengthened the connection of Antioch to the Byzantine Empire. The marriage also strengthened the position of Maria's mother Constance, who now held the regency of Antioch. According to Niketas Choniates, Maria

"...was like unto the laughter-loving, golden Aphrodite, the white-armed and ox-eyed Hera, the long-necked and beautiful ankled Laconian, whom the ancients deified for their beauty, and all the rest of the beauties whose good looks have been preserved in distinguished books and histories."

For several years, Maria was childless. In 1166 she miscarried a son, considered a tragedy by her husband and the population.^[2] In 1169 Maria finally gave birth to a son, the future emperor Alexios II Komnenos. She played a role in the political and diplomatic life of Constantinople. French being her mother tongue, she was able to observe the double-dealing of the hypoboleus (court interpreter) Aaron Isaakios, who was quietly advising Westerners not to pay too much for the Emperor's favour. As a result, Manuel had Aaron blinded.^[3]

Regency

After the death of Manuel in 1180, Maria officially became a nun with the name "Xene" (translated foreigner), but in reality she acted as regent for their son Alexios II.^[2] Despite being a nun she had many ambitious suitors, but she chose another Alexios, the prōtosebastos and prōtovestiarios, a nephew of Manuel and uncle of Maria Komnene, former queen of Jerusalem, as an advisor and lover, causing a scandal among the Greek population. As a Westerner who favoured the Italian merchants, Maria was opposed by the Greeks, and her regency was widely considered incompetent.

The leaders of the opposition were her stepdaughter, the porphyrogenita Maria Komnene and her husband, the Caesar Renier of Montferrat, though himself a fellow Latin. The porphyrogenita Maria may have considered herself the rightful heir, as the elder child of Manuel; she was almost as old as her stepmother Maria. Maria and Renier gained the support of the Patriarch Theodosius I and used Hagia Sophia as a base of operations. Alexios had the patriarch arrested, leading to open warfare on the streets of Constantinople.

Execution

Manuel's cousin Andronikos Komnenos, who had been exiled during Manuel's reign, was invited back by the porphyrogenita Maria, and marched on Constantinople in 1182. He provoked the citizens into a massacre of the Latin inhabitants, mostly Venetian and Genoese merchants.

After gaining control of the city, he had the Porphyrogenita and Renier poisoned, and then had Empress Maria arrested and imprisoned in the monastery of St. Diomedes or in a prison nearby. The empress tried to seek help from her brother-in-law King Béla III of Hungary, to no avail. Andronikos had Alexios II sign the order for his mother's execution, and appointed his own son Manuel and the sebastos George to execute her, but they refused. Instead, according to Niketas, Maria was strangled by the hetaireiarches Constantine Tripsychos and the eunuch Pterygeonites, and buried in an unmarked grave on a nearby beach.^[4]

Presumably owing to the secrecy surrounding her death, alternative versions of her death circulated, such as that she was tied up in a sack and drowned.^[5] Andronikos had himself crowned co-emperor, but Alexios II was soon murdered as well, and Andronikos took full control of the empire. Sometime later Andronikos also defaced or destroyed most images of Maria in Constantinople.