The Mesostriatal system is a term sometimes used to identify the midbrain dopamine projections into the striatum and cortex. It has been described as a combination of the mesolimbic and nigrostriatal dopamine projections, and has been described as being partially asymmetric.[1]

Research

It has been referred to in the context of α-melanocyte stimulating hormones effect on dopamine activity in the mesostriatal system.[2] Research identifying cholinergic projections into these mesostriatal nuclei have been performed, revealing that the midbrain dopaminergic nuclei receive projections from the pedunculopontine tegmentum and laterodorsal pontine tegmentum.[3] The mesostriatal system has also been implicated in reward learning, coding predictions.[4] This anatomical classification has also been used in the context of parkinson research.[5]

References

  1. Molochnikov, Ilana; Cohen, Dana (1 January 2014). "Hemispheric differences in the mesostriatal dopaminergic system". Frontiers in Systems Neuroscience. 8: 110. doi:10.3389/fnsys.2014.00110. PMC 4052732. PMID 24966817.
  2. Roseberry, Aaron G.; Stuhrman, Katherine; Dunigan, Anna I. (1 September 2015). "Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein". Neuroscience and Biobehavioral Reviews. 56: 15–25. doi:10.1016/j.neubiorev.2015.06.020. ISSN 1873-7528. PMID 26116876. S2CID 43619316.
  3. Zhou, Fu-Ming; Wilson, Charles; Dani, John A. (1 February 2003). "Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems". The Neuroscientist. 9 (1): 23–36. doi:10.1177/1073858402239588. ISSN 1073-8584. PMID 12580337. S2CID 8266496.
  4. Chase, Henry W.; Kumar, Poornima; Eickhoff, Simon B.; Dombrovski, Alexandre Y. (9 January 2017). "Reinforcement Learning Models and Their Neural Correlates: An Activation Likelihood Estimation Meta-Analysis". Cognitive, Affective, & Behavioral Neuroscience. 15 (2): 435–459. doi:10.3758/s13415-015-0338-7. ISSN 1530-7026. PMC 4437864. PMID 25665667.
  5. Cools, A. R. (1 March 1990). "Role of neostriatal and mesostriatal or mesolimbic dopaminergic fibres in Parkinson's disease with and without dementia: prospects, concepts and facts". Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology. 10 (1): 15–34. ISSN 0285-5313. PMID 2220127.
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