Methanogen homoaconitase
Identifiers
EC no.4.2.1.114
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming).[1] This enzyme catalyses the following chemical reaction

(R)-2-hydroxybutane-1,2,4-tricarboxylate (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)
(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.

References

  1. Drevland RM, Jia Y, Palmer DR, Graham DE (October 2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". The Journal of Biological Chemistry. 283 (43): 28888–96. doi:10.1074/jbc.m802159200. PMC 2662002. PMID 18765671.
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