Sir

Anthony Epstein

CBE FRS FMedSci
Born
Michael Anthony Epstein

(1921-05-18) 18 May 1921
NationalityBritish
EducationSt Paul's School
Alma materTrinity College, Cambridge
Middlesex Hospital Medical School
OccupationVirology
Known forEpstein–Barr virus
AwardsPaul Ehrlich and Ludwig Darmstaedter Prize (1973)
Royal Medal (1992)

Sir Michael Anthony Epstein CBE FRS FMedSci (born 18 May 1921)[1] is a British pathologist and academic. He is one of the discoverers of the Epstein–Barr virus, along with Yvonne Barr and Bert Achong.[2][3][4][5][6][7][8][9]

Early and personal life

Epstein was born on 18 May 1921,[10][11] and educated at St Paul's School in London,[12] Trinity College, Cambridge, and Middlesex Hospital Medical School.

In 2006, Epstein was awarded a D.Sc. from Bristol. Epstein turned 100 in May 2021.[13][14] He is a Patron of Humanists UK.[10]

Career

Epstein was Professor of Pathology, 1968–1985 (now professor emeritus), head of department, 1968–1982[15] at the University of Bristol.[16] In 1979 he was elected a Fellow of the Royal Society of London and was its vice-president[1] from 1986 to 1991. He was awarded its Royal Medal in 1992.[17] Epstein was awarded the CBE in 1985,[18] and knighted in 1991.[1] He was a fellow of Wolfson College, Oxford, from 1986 until 2001, and has been an honorary fellow since 2001. Epstein was also a founding Fellow of the Academy of Medical Sciences in 1998.[19]

Burkitt lymphoma studies

Epstein was the first person to propose that Burkitt's lymphoma was a cancer caused by a virus. Upon hearing a lecture given by Denis Parsons Burkitt in 1961 about this newly described cancer, Epstein changed his research focus from cancer causing viruses in chickens to searching for a viral origin of Burkitt's lymphoma.[20] After more than two years of working with tumour cells from Burkitt's patients and subsequently working to isolate a virus from them, the Epstein–Barr virus was finally discovered in February 1964.[21]

References

  1. 1 2 3 "Anthony Epstein". Royal Society. Archived from the original on 17 November 2015. Retrieved 25 October 2021.
  2. ↑ Bornkamm, G. W.; Delius, H.; Zimber, U.; Hudewentz, J.; Epstein, M. A. (1980). "Comparison of Epstein–Barr virus strains of different origin by analysis of the viral DNAs". Journal of Virology. 35 (3): 603–618. doi:10.1128/JVI.35.3.603-618.1980. PMC 288854. PMID 6252328.
  3. ↑ North, J. R.; Morgan, A. J.; Thompson, J. L.; Epstein, M. A. (1982). "Purified Epstein-Barr virus Mr 340,000 glycoprotein induces potent virus-neutralizing antibodies when incorporated in liposomes". Proceedings of the National Academy of Sciences of the United States of America. 79 (23): 7504–7508. Bibcode:1982PNAS...79.7504N. doi:10.1073/pnas.79.23.7504. PMC 347368. PMID 6296836.
  4. ↑ Gaston, J. S.; Rickinson, A. B.; Yao, Q. Y.; Epstein, M. A. (1986). "The abnormal cytotoxic T cell response to Epstein–Barr virus in rheumatoid arthritis is correlated with disease activity and occurs in other arthropathies". Annals of the Rheumatic Diseases. 45 (11): 932–936. doi:10.1136/ard.45.11.932. PMC 1002022. PMID 2878645.
  5. ↑ Epstein, M. A.; Morgan, A. J. (1983). "Clinical consequences of Epstein–Barr virus infection and possible control by an anti-viral vaccine". Clinical and Experimental Immunology. 53 (2): 257–271. PMC 1535689. PMID 6309441.
  6. ↑ Rickinson, A. B.; Finerty, S.; Epstein, M. A. (1982). "Interaction of Epstein–Barr virus with leukaemic B cells in vitro. I. Abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells". Clinical and Experimental Immunology. 50 (2): 347–354. PMC 1536694. PMID 6295671.
  7. ↑ Rickinson, A. B.; Crawford, D.; Epstein, M. A. (1977). "Inhibition of the in vitro outgrowth of Epstein–Barr virus-transformed lymphocytes by thymus-dependent lymphocytes from infectious mononucleosis patients". Clinical and Experimental Immunology. 28 (1): 72–79. PMC 1540876. PMID 193663.
  8. ↑ Yao, Q. Y.; Rickinson, A. B.; Gaston, J. S.; Epstein, M. A. (1986). "Disturbance of the Epstein-Barr virus-host balance in rheumatoid arthritis patients: A quantitative study". Clinical and Experimental Immunology. 64 (2): 302–310. PMC 1542331. PMID 3017620.
  9. ↑ Epstein, M. A.; Randle, B. J.; Finerty, S.; Kirkwood, J. K. (1986). "Not all potently neutralizing, vaccine-induced antibodies to Epstein-Barr virus ensure protection of susceptible experimental animals". Clinical and Experimental Immunology. 63 (3): 485–490. PMC 1577551. PMID 3011324.
  10. 1 2 "Professor Sir Anthony Epstein CBE FRS". Humanists UK. Retrieved 25 October 2021.
  11. ↑ "Sir Anthony Epstein". Wolfson College, Oxford. Archived from the original on 13 October 2020. Retrieved 25 October 2021.
  12. ↑ Transactions of the Medical Society of London, Vol. 117 (2000), p. 66.
  13. ↑ EBV Association: Sir Antony Epstein.
  14. ↑ "The 100th birthday of Prof. Sir Anthony Epstein". EAHP. 11 May 2021. Retrieved 31 October 2021.
  15. ↑ Who's Who: Epstein, Sir (Michael) Anthony.
  16. ↑ "Sir Michael Anthony Epstein". Oxford Reference. Retrieved 25 October 2021.
  17. ↑ "Royal Medal - Award winners". Royal Society. Archived from the original on 22 December 2015. Retrieved 25 October 2021 – via Google Drive.
  18. ↑ The Palgrave Dictionary of Anglo-Jewish History (2011), p. 258.
  19. ↑ "Epstein, Anthony". Academy of Europe. Archived from the original on 7 November 2017. Retrieved 25 October 2021.
  20. ↑ McGrath, Paula (6 April 2014). "Cancer virus discovery helped by delayed flight". BBC News, Health. Retrieved 4 November 2015.
  21. ↑ Epstein, A. (2012). "Burkitt Lymphoma and the discovery of Epstein–Barr virus". British Journal of Haematology. 156 (6): 777–779. doi:10.1111/j.1365-2141.2011.09008.x. PMID 22233499. S2CID 27417152.
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