First quarter

Michigan State started the game with a 66-yard drive that ended with a Brett Swenson 32-yard field goal. Northwestern's first drive ended with quarterback C. J. Bachér finding Ross Lane for a 5-yard touchdown that gave the Wildcats a 7–3 lead.

Second quarter

The Wildcats' first drive of the second quarter resulted in Bachér rushing for a 2-yard touchdown. The Spartans were forced to punt on the ensuing drive. Northwestern's Joel Howells kicked a 30-yard field goal on the next drive. On the following drive, Michigan State was once again forced to punt. After the punt, Northwestern scored another touchdown on a Brandon Roberson 18-yard pass to Shaun Herbert. Michigan State's woes continued on their next drive, when they fumbled the football. However, Howells missed a 36-yard field goal at the end of the first half. The half ended with the Spartans down 24-3.

Third quarter

Northwestern began the third quarter with an 80-yard drive that resulted in a Bachér 22-yard touchdown pass to Lane. On the first play of the next drive, Drew Stanton was intercepted. Northwestern capitalized on the great field position with Herbert catching a 5-yard touchdown pass, giving Northwestern a 38–3 lead. Michigan State began the comeback with a nine play, 65 yard drive that was capped off with an 18-yard touchdown pass from quarterback Stanton to running back Jehuu Caulcrick. Following a Northwestern punt, Michigan State scored again, finishing an eight play, 53-yard drive with a 4-yard touchdown run from A.J. Jimmerson. On the ensuing drive, the Wildcats had gained 69 yards in only 5 plays when Bachér was intercepted at the goal line by Michigan State middle linebacker Kaleb Thornhill. The quarter ended with the Spartans down 38–17.

Fourth quarter

Michigan State's chances of completing the comeback appeared to be finished early in the fourth quarter when backup quarterback Brian Hoyer had his 6th pass of the drive intercepted by Northwestern a minute in. However, after failing to convert a short third down at midfield, the Wildcats had their punt blocked by Devin Thomas and returned for a touchdown by Ashton Henderson. Northwestern's next two drives also ended in punts, and each ensuing Spartan drive resulted in a touchdown. With the score tied at 38, the Wildcats had the ball on their own 15 yard line with 3:32 left in regulation. On the first play of the series, Bachér was intercepted by the Spartans' Travis Key at the Northwestern 40. The interception was returned to the 30 yard line. The Spartans ran the ball for the duration of the drive, advancing the ball to Northwestern's 11 yard line with 18 seconds left. MSU kicker Swenson hit a 28-yard field goal to give the Spartans the lead.

The Wildcats would get the ball one more time, returning the ensuing kickoff to their own 37 yard line. Following an offsides penalty which moved the ball to the 42 yard line, Northwestern's final play for the end zone was unsuccessful and the Spartans won 41–38.