MicroRNA 196b

MIR196B
Identifiers
Aliases	MIR196B, MIRN196B, miR-196b, miRNA196B, microRNA 196b
External IDs	OMIM: 609688 GeneCards: MIR196B
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,169,563 bp
RNA expression pattern
	Top expressed in
	endometrium; ; blood; ; left adrenal gland; ; glomerulus; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; prostate; ; subcutaneous adipose tissue; ; pituitary gland; ; tibial nerve;
	n/a
	More reference expression data
	n/a
Orthologs
	442920
	n/a
	ENSG00000283745
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

MicroRNA 196b is a protein that in humans is encoded by the MIR196B gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs.

miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000283745 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 196b". Retrieved 2017-12-20.

Tay Y, Peter S, Rigoutsos I, Barahona P, Ahmed S, Dröge P (2009). "Insights into the regulation of a common variant of HMGA2 associated with human height during embryonic development". Stem Cell Rev. 5 (4): 328–33. doi:10.1007/s12015-009-9095-8. PMID 20058197. S2CID 297093.
Schotte D, Lange-Turenhout EA, Stumpel DJ, Stam RW, Buijs-Gladdines JG, Meijerink JP, Pieters R, Den Boer ML (2010). "Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia". Haematologica. 95 (10): 1675–82. doi:10.3324/haematol.2010.023481. PMC 2948092. PMID 20494936.
Bhatia S, Kaul D, Varma N (2010). "Potential tumor suppressive function of miR-196b in B-cell lineage acute lymphoblastic leukemia". Mol. Cell. Biochem. 340 (1–2): 97–106. doi:10.1007/s11010-010-0406-9. PMID 20549547. S2CID 12753166.
Coskun E, von der Heide EK, Schlee C, Kühnl A, Gökbuget N, Hoelzer D, Hofmann WK, Thiel E, Baldus CD (2011). "The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia". Leuk. Res. 35 (2): 208–13. doi:10.1016/j.leukres.2010.05.007. PMID 20570349.
Tsai KW, Hu LY, Wu CW, Li SC, Lai CH, Kao HW, Fang WL, Lin WC (2010). "Epigenetic regulation of miR-196b expression in gastric cancer". Genes Chromosomes Cancer. 49 (11): 969–80. doi:10.1002/gcc.20804. PMID 20662076. S2CID 24753276.
Bhatia S, Kaul D, Varma N (2011). "Functional genomics of tumor suppressor miR-196b in T-cell acute lymphoblastic leukemia". Mol. Cell. Biochem. 346 (1–2): 103–16. doi:10.1007/s11010-010-0597-0. PMID 20924650. S2CID 24195482.
Grek M, Piekarska A, Bartkowiak J, Fendler W, Kuydowicz J, Wroblewski P, Paradowski M, Sidorkiewicz M (2011). "Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells". Int. J. Mol. Med. 28 (5): 875–80. doi:10.3892/ijmm.2011.748. PMID 21750860.
de Oliveira JC, Scrideli CA, Brassesco MS, Morales AG, Pezuk JA, Queiroz Rde P, Yunes JA, Brandalise SR, Tone LG (2012). "Differential miRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features". Leuk. Res. 36 (3): 293–8. doi:10.1016/j.leukres.2011.10.005. PMID 22099053.
Liao YL, Hu LY, Tsai KW, Wu CW, Chan WC, Li SC, Lai CH, Ho MR, Fang WL, Huang KH, Lin WC (2012). "Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells". Carcinogenesis. 33 (4): 760–9. doi:10.1093/carcin/bgs023. PMC 3324441. PMID 22298639.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000283745 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 196b". Retrieved 2017-12-20.

[1]

[2]

[3]

Function

References

Further reading