Mihaela Zavolan
Mihaela Zavolan (2015)
NationalityRomanian
Scientific career
FieldsSystems Biology
InstitutionsVictor Babeș University of Medicine and Pharmacy, Timișoara, University of New Mexico, Santa Fe Institute, Los Alamos National Laboratory, Rockefeller University, Swiss Institute of Bioinformatics, Biozentrum University of Basel

Mihaela Zavolan is a system biologist and Professor at the Biozentrum of the University of Basel.

Life

Mihaela Zavolan studied medicine at the University of Medicine and Pharmacy in Timișoara, Romania. She then graduated with a PhD in Computer Science from the University of New Mexico in Albuquerque, USA. Between 1993 and 2003 Mihaela Zavolan carried out research in the US, at the Santa Fe Institute in Santa Fe, the Los Alamos National Laboratory in Los Alamos, as well as at the Rockefeller University in New York. In 2003, Mihaela Zavolan was appointed Professor of Computational and Systems Biology at the Biozentrum of the University of Basel.[1] She is also a group leader of the Swiss Institute of Bioinformatics (SIB).[2]

Work

The main focus of the research in Mihaela Zavolan's group is of microRNAs (miRNAs).[3] These 22 nucleotides long RNA molecules regulate the expression of protein coding genes, thereby controlling cell differentiation, metabolism and immune responses. Through the development of high-throughput experimental methods and computational analyses, Zavolan has contributed to the discovery of many miRNAs in various organisms ranging from viruses to humans.[4] She has developed algorithms to predict miRNA genes and miRNA targets, and has worked on the development of the CLIP method (cross-linking and immunoprecipitation) for mapping the binding sites of RNA-binding proteins in RNAs.[5] Recently, her group used CLIP binding site data to infer a biophysical model of miRNA-target interaction, which can be used to predict the strength between of interactions between miRNAs and their targets on mRNAs and long non-coding RNA.[6]

Awards and honors

References

  1. ↑ "Curriculum Vitae". Biozentrum.unibas.ch. Retrieved 2014-01-27.
  2. ↑ "SIB Group M. Zavolan". isb-sib.ch. Retrieved 2014-01-27.
  3. ↑ "Research Group Mihaela Zavolan". eurasnet.info. Archived from the original on 2015-05-26. Retrieved 2014-01-27.
  4. ↑ "New biophysical model predicts regulation by microRNAs". biozentrum.unibas.ch. Retrieved 2014-01-27.
  5. ↑ Kishore, Shivendra; Jaskiewicz, Lukasz; Burger, Lukas; Hausser, Jean; Khorshid, Mohsen; Zavolan, Mihaela (2011). "A quantitative analysis of CliP methods for identifying binding sites of RNA-binding proteins". Nature Methods. 8 (7): 559–564. doi:10.1038/nmeth.1608. PMID 21572407. S2CID 5313093.
  6. ↑ Khorshid, Mohsen; Hausser, Jean; Zavolan, Mihaela; Van Nimwegen, Erik (2013). "A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets". Nature Methods. 10 (3): 253–255. doi:10.1038/nmeth.2341. PMID 23334102. S2CID 205421282.
  7. ↑ "ERC Starting Grant for Mihaela Zavolan". biozentrum.unibas.ch. Retrieved 2014-01-27.
  8. ↑ "Success for HFSP alumni in the latest competition for ERC Starting Grants". hfsp.org. Retrieved 2014-01-27.
  9. ↑ Elected Member of the Academia Europaea ae-info.org. Retrieved 2014-9-04
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