Muscarinic toxin 1 (MT1) belongs to the family of small peptides of 65 amino acid residues derived from the venom of African mamba snakes (Dendroaspis angusticeps), with dual specificity for muscarinic receptor subtypes M1 (Ki=20–35 nM)[1] and M4 (Ki=30–72 nM).[1] Muscarinic toxins like the nicotinic toxins have the three-finger fold structure, characteristic of the large superfamily of toxins that act at cholinergic synapses.
| Muscarinic toxin 1 | |
|---|---|
 Crystal structure of the muscarinic toxin MT1(MT1) from PDB 4DO8 [2] | |
| Identifiers | |
| Symbol | MT1 |
| SCOP2 | 1F94 / SCOPe / SUPFAM |
References
- 1 2 Servent D, Blanchet G, Mourier G, Marquer C, Marcon E, Fruchart-Gaillard C (November 2011). "Muscarinic toxins". Toxicon. 58 (6–7): 455–63. doi:10.1016/j.toxicon.2011.08.004. PMID 21906611.
- ↑ PDB: 4DO8: Fruchart-Gaillard C, Mourier G, Blanchet G, Vera L, Gilles N, Ménez R, Marcon E, Stura EA, Servent D (June 2012). "Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors". PLOS ONE. 7 (6): e39166. Bibcode:2012PLoSO...739166F. doi:10.1371/journal.pone.0039166. PMC 3375269. PMID 22720062.
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