| neighbor of BRCA1 gene 2 | |
|---|---|
| Identifiers | |
| Symbol | NBR2 |
| NCBI gene | 10230 |
| HGNC | 20691 |
| RefSeq | NM_005821 |
| Other data | |
| Locus | Chr. 17 q21 |
NBR2 is a gene best known for its location near the breast cancer associated gene BRCA1.[1] Like BRCA1, NBR2 has been a subject of research,[2] but links to breast cancer are currently inconclusive.
NBR2 recently was identified as a glucose starvation-induced long non-coding RNA. NBR2 interacts with AMP-activated protein kinase (AMPK), a critical energy sensor in most eukaryotic cells, and promotes AMPK function to mediate energy stress response. Knockdown of NBR2 attenuates energy stress-induced AMPK activation, resulting in unchecked cell cycling, altered apoptosis/autophagy response, and increased tumour development in vivo.[3][4] It is now appreciated that NBR2, a former junk gene, plays critical roles in tumor suppression.[5]
References
- ↑ Xu CF, Brown MA, Nicolai H, Chambers JA, Griffiths BL, Solomon E (1997). "Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene". Hum. Mol. Genet. 6 (7): 1057–62. doi:10.1093/hmg/6.7.1057. PMID 9215675.
- ↑ Auriol E, Billard LM, Magdinier F, Dante R (2005). "Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus". Nucleic Acids Res. 33 (13): 4243–54. doi:10.1093/nar/gki729. PMC 1181861. PMID 16052033.
- ↑ Liu, Xiaowen; Xiao, Zhen-Dong; Han, Leng; Zhang, Jiexin; Lee, Szu-Wei; Wang, Wenqi; Lee, Hyemin; Zhuang, Li; Chen, Junjie (2016-04-01). "LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress". Nature Cell Biology. 18 (4): 431–442. doi:10.1038/ncb3328. ISSN 1476-4679. PMC 4814347. PMID 26999735.
- ↑ Liu, Xiaowen; Xiao, Zhen-Dong; Gan, Boyi (2016-08-02). "An lncRNA switch for AMPK activation". Cell Cycle. 15 (15): 1948–1949. doi:10.1080/15384101.2016.1184515. ISSN 1551-4005. PMC 4968966. PMID 27152502.
- ↑ Xiao, Zhen-Dong; Liu, Xiaowen; Zhuang, Li; Gan, Boyi (2016-07-03). "NBR2: A former junk gene emerges as a key player in tumor suppression". Molecular & Cellular Oncology. 3 (4): e1187322. doi:10.1080/23723556.2016.1187322. PMC 4972102. PMID 27652330.
External links
- NBR2 human gene location in the UCSC Genome Browser.
- NBR2 human gene details in the UCSC Genome Browser.
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