NKRF (gene)

NKRF
Identifiers
Aliases	NKRF, ITBA4, NRF, NFKB repressing factor
External IDs	OMIM: 300440 MGI: 1924536 HomoloGene: 84816 GeneCards: NKRF
Gene location (Human)
Chr.	X chromosome (human)
End	119,606,443 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	36,167,166 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; Brodmann area 23; ; superior frontal gyrus; ; middle temporal gyrus; ; entorhinal cortex; ; Brodmann area 46; ; pons; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	pontine nuclei; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; primitive streak; ; facial motor nucleus; ; spinal cord; ; superior colliculus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; nucleic acid binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleolus; nucleoplasm;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	55922
	77286
	ENSG00000186416
	ENSMUSG00000044149
	O15226
	Q8BY02
	NM_001173487; NM_001173488; NM_017544
	NM_029891
	NP_060014
	NP_084167
	Wikidata
View/Edit Human	View/Edit Mouse

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.^[5]^[6]

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.

The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.
1 2 "Entrez Gene: NKRF NF-kappaB repressing factor".

Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25". Gene. 192 (2): 291–8. doi:10.1016/S0378-1119(97)00108-X. PMID 9224902.
Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. Bibcode:2002PNAS...9914212F. doi:10.1073/pnas.212306199. PMC 137863. PMID 12381793.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor". Mol. Cells. 16 (3): 397–401. doi:10.1016/S1016-8478(23)13818-0. PMID 14744032.
Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF". J. Cell Sci. 117 (Pt 16): 3447–58. doi:10.1242/jcs.01129. PMID 15226370.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor". Mol. Cell. Biol. 25 (17): 7473–83. doi:10.1128/MCB.25.17.7473-7483.2005. PMC 1190279. PMID 16107696.
Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells". Mol. Carcinog. 46 (5): 402–13. doi:10.1002/mc.20288. PMID 17186550. S2CID 33896417.
Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element". RNA. 13 (8): 1328–40. doi:10.1261/rna.545407. PMC 1924892. PMID 17592041.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10562553-5] Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.

[entrez-6] 1 2 "Entrez Gene: NKRF NF-kappaB repressing factor".

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References

Further reading