NOD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNOD1, CARD4, CLR7.1, NLRC1, nucleotide binding oligomerization domain containing 1
External IDsOMIM: 605980 MGI: 1341839 HomoloGene: 4440 GeneCards: NOD1
Orthologs
SpeciesHumanMouse
Entrez

10392

107607

Ensembl

ENSG00000106100

ENSMUSG00000038058

UniProt

Q9Y239

Q8BHB0

RefSeq (mRNA)

NM_006092
NM_001354849

NM_001171007
NM_172729

RefSeq (protein)

NP_006083
NP_001341778

NP_001164478
NP_766317

Location (UCSC)Chr 7: 30.42 – 30.48 MbChr 6: 54.9 – 54.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene.[5][6] It recognizes bacterial molecules and stimulates an immune reaction .[7]

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial peptidoglycan. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000106100 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038058 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (May 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
  6. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (May 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
  7. Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.

Further reading

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