PDS5B

PDS5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5HDT
Identifiers
Aliases	PDS5B, APRIN, AS3, CG008, PDS5 cohesin associated factor B
External IDs	OMIM: 605333 MGI: 2140945 HomoloGene: 41001 GeneCards: PDS5B
Gene location (Human)
Chr.	Chromosome 13 (human)
End	32,778,019 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	150,734,155 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; endothelial cell; ; tibia; ; bone marrow cells; ; oocyte; ; ganglionic eminence; ; endometrium; ; middle temporal gyrus; ; canal of the cervix;
	Top expressed in
	superior cervical ganglion; ; otolith organ; ; utricle; ; nucleus accumbens; ; renal corpuscle; ; olfactory tubercle; ; vas deferens; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ATP binding; DNA binding;
Cellular component	chromosome; cytosol; chromatin; chromosome, centromeric region; nucleoplasm; nucleus;
Biological process	cell division; cell cycle; cell population proliferation; regulation of cell population proliferation; mitotic sister chromatid cohesion; negative regulation of cell population proliferation; DNA repair; lens development in camera-type eye; enteric nervous system development; neuroblast migration;
	Sources:Amigo / QuickGO
Orthologs
	23047
	100710
	ENSG00000083642
	ENSMUSG00000034021
	Q9NTI5
	Q4VA53
	NM_015032; NM_015928
	NM_175310; NM_001346503
	NP_055847
	NP_001333432; NP_780519
	Wikidata
View/Edit Human	View/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein that in humans is encoded by the PDS5B gene.^[5]^[6]^[7] It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000083642 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034021 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J, et al. (Feb 1997). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99. doi:10.1006/geno.1996.0428. PMID 8812419.
↑ Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM (May 1999). "Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus". J Steroid Biochem Mol Biol. 68 (1–2): 41–50. doi:10.1016/S0960-0760(98)00165-4. PMID 10215036. S2CID 32542980.
↑ "Entrez Gene: APRIN androgen-induced proliferation inhibitor".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000083642 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034021 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812419-5] Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J, et al. (Feb 1997). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99. doi:10.1006/geno.1996.0428. PMID 8812419.

[pmid10215036-6] Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM (May 1999). "Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus". J Steroid Biochem Mol Biol. 68 (1–2): 41–50. doi:10.1016/S0960-0760(98)00165-4. PMID 10215036. S2CID 32542980.

[entrez-7] "Entrez Gene: APRIN androgen-induced proliferation inhibitor".

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