PDZD2
Identifiers
AliasesPDZD2, AIPC, PAPIN, PDZK3, PIN1, PDZ domain containing 2
External IDsOMIM: 610697 MGI: 1922394 HomoloGene: 23393 GeneCards: PDZD2
Orthologs
SpeciesHumanMouse
Entrez

23037

68070

Ensembl

ENSG00000133401

ENSMUSG00000022197

UniProt

O15018

n/a

RefSeq (mRNA)

NM_015022
NM_178140

NM_001081064

RefSeq (protein)

NP_835260

n/a

Location (UCSC)Chr 5: 31.64 – 32.11 MbChr 15: 12.36 – 12.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene.[5][6]

Function

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.[6]

Interactions

PDZD2 has been shown to interact with PKP4.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000133401 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022197 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  6. 1 2 "Entrez Gene: PDZD2 PDZ domain containing 2".
  7. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
  8. Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.

Further reading


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