PIK3AP1

PIK3AP1
Identifiers
Aliases	PIK3AP1, BCAP, phosphoinositide-3-kinase adaptor protein 1
External IDs	OMIM: 607942 MGI: 1933177 HomoloGene: 12848 GeneCards: PIK3AP1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	96,720,514 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,373,541 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; pancreatic epithelial cell; ; monocyte; ; pancreatic ductal cell; ; appendix; ; blood; ; spongy bone; ; bone marrow; ; liver; ; bone marrow cells;
	Top expressed in
	submandibular gland; ; spleen; ; blood; ; Paneth cell; ; liver; ; right lung lobe; ; lymph node; ; carotid body; ; conjunctival fornix; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol 3-kinase regulatory subunit binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; signaling receptor binding;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane;
Biological process	positive regulation of phosphatidylinositol 3-kinase signaling; toll-like receptor 9 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; regulation of inflammatory response; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	118788
	83490
	ENSG00000155629
	ENSMUSG00000025017
	Q6ZUJ8
	Q9EQ32
	NM_152309
	NM_031376
	NP_689522
	NP_113553
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155629 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025017 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med. 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.
↑ Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity. 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.
↑ "Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Maruoka M, Suzuki J, Kawata S, et al. (2005). "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases". FEBS Lett. 579 (14): 2986–90. doi:10.1016/j.febslet.2005.04.052. PMID 15893754. S2CID 20802390.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155629 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025017 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1251844-5] Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med. 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.

[pmid11163197-6] Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity. 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.

[entrez-7] "Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading