PLA2G4C
Identifiers
Aliases	PLA2G4C, CPLA2-gamma, phospholipase A2 group IVC
External IDs	OMIM: 603602 MGI: 1196403 HomoloGene: 115256 GeneCards: PLA2G4C
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,047,843 bp[1] End 48,110,817 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 7.84 cM Start 13,058,580 bp[2] End 13,094,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve vastus lateralis muscle corpus callosum triceps brachii muscle substantia nigra gastrocnemius muscle oocyte external globus pallidus deltoid muscle inferior olivary nucleus Top expressed in secondary oocyte epithelium of stomach Paneth cell morula parotid gland bone marrow ovary jejunum blastocyst seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase activity calcium-independent phospholipase A2 activity phospholipid binding hydrolase activity phospholipase A2 activity phospholipase A1 activity lysophospholipase activity calcium ion binding calcium-dependent phospholipid binding calcium-dependent phospholipase A2 activity Cellular component cytosol endoplasmic reticulum membrane membrane nuclear envelope nucleoplasm cell cortex cytoplasm Biological process intracellular signal transduction phosphatidylethanolamine acyl-chain remodeling glycerophospholipid catabolic process lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process birth phospholipid catabolic process phospholipid metabolic process metabolism inflammatory response arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8605 232889 Ensembl ENSG00000105499 ENSMUSG00000033847 UniProt Q9UP65 Q64GA5 RefSeq (mRNA) NM_001159322 NM_001159323 NM_003706 NM_001004762 NM_001168504 RefSeq (protein) NP_001152794 NP_001152795 NP_003697 NP_003697.2 NP_001004762 NP_001161976 Location (UCSC) Chr 19: 48.05 – 48.11 Mb Chr 7: 13.06 – 13.09 Mb PubMed search [3] [4]
Wikidata
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Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.^[5][6]

References

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.{{cite journal}}: CS1 maint: overridden setting (link)
• Wu T, Angus CW, Yao XL, et al. (1997). "P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 272 (27): 17145–53. doi:10.1074/jbc.272.27.17145. PMID 9202034.{{cite journal}}: CS1 maint: overridden setting (link)
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.{{cite journal}}: CS1 maint: overridden setting (link)
• Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
• Smith JS, Tachibana I, Pohl U, et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.{{cite journal}}: CS1 maint: overridden setting (link)
• Hartmann C, Johnk L, Sasaki H, et al. (2002). "Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas". Brain Pathol. 12 (2): 178–82. doi:10.1111/j.1750-3639.2002.tb00432.x. PMC 8095768. PMID 11958371. S2CID 2579203.{{cite journal}}: CS1 maint: overridden setting (link)
• Stewart A, Ghosh M, Spencer DM, Leslie CC (2002). "Enzymatic properties of human cytosolic phospholipase A(2)gamma". J. Biol. Chem. 277 (33): 29526–36. doi:10.1074/jbc.M204856200. PMID 12039969.
• Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.{{cite journal}}: CS1 maint: overridden setting (link)
• Asai K, Hirabayashi T, Houjou T, et al. (2003). "Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress". J. Biol. Chem. 278 (10): 8809–14. doi:10.1074/jbc.M212117200. PMID 12502717.{{cite journal}}: CS1 maint: overridden setting (link)
• Jenkins CM, Han X, Yang J, et al. (2004). "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis". Biochemistry. 42 (40): 11798–807. doi:10.1021/bi034611q. PMID 14529291.{{cite journal}}: CS1 maint: overridden setting (link)
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.{{cite journal}}: CS1 maint: overridden setting (link)
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.{{cite journal}}: CS1 maint: overridden setting (link)
• Dong M, Johnson M, Rezaie A, et al. (2005). "Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis". Clin. Cancer Res. 11 (6): 2265–71. doi:10.1158/1078-0432.CCR-04-1079. PMID 15788676.{{cite journal}}: CS1 maint: overridden setting (link)
• Yan W, Jenkins CM, Han X, et al. (2005). "The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling". J. Biol. Chem. 280 (29): 26669–79. doi:10.1074/jbc.M502358200. PMID 15908428.{{cite journal}}: CS1 maint: overridden setting (link)
• Yamashita A, Kamata R, Kawagishi N, et al. (2005). "Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)". J. Biochem. 137 (5): 557–67. doi:10.1093/jb/mvi067. PMID 15944408.{{cite journal}}: CS1 maint: overridden setting (link)
• Zhao X, Wang D, Zhao Z, et al. (2006). "Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells". J. Biol. Chem. 281 (39): 29357–68. doi:10.1074/jbc.M513105200. PMID 16882668.{{cite journal}}: CS1 maint: overridden setting (link)