POLR2F
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2F, HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F, RNA polymerase II subunit F, RNA polymerase II, I and III subunit F
External IDsOMIM: 604414 MGI: 1349393 HomoloGene: 7178 GeneCards: POLR2F
Orthologs
SpeciesHumanMouse
Entrez

5435

69833

Ensembl

ENSG00000100142

ENSMUSG00000033020

UniProt

P61218

P61219

RefSeq (mRNA)

NM_001301129
NM_001301130
NM_001301131
NM_021974
NM_001363825

NM_027231

RefSeq (protein)

NP_001288058
NP_001288059
NP_001288060
NP_068809
NP_001350754

NP_081507

Location (UCSC)Chr 22: 37.95 – 38.04 MbChr 15: 79.03 – 79.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.[5]

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.[6]

Interactions

POLR2F has been shown to interact with POLR2C.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100142 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033020 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pusch C, Wang Z, Roe B, Blin N (September 1996). "Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity". Genomics. 34 (3): 440–2. doi:10.1006/geno.1996.0312. PMID 8786150.
  6. "Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F".
  7. Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

Further reading

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