PLPP1
Identifiers
AliasesPLPP1, LLP1a, LPP1, PAP-2a, PAP2, PPAP2A, phospholipid phosphatase 1
External IDsOMIM: 607124 HomoloGene: 7484 GeneCards: PLPP1
Orthologs
SpeciesHumanMouse
Entrez

8611

n/a

Ensembl

ENSG00000067113

n/a

UniProt

O14494

n/a

RefSeq (mRNA)

NM_003711
NM_176895

n/a

RefSeq (protein)

NP_003702
NP_795714

n/a

Location (UCSC)Chr 5: 55.42 – 55.53 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.[3][4]

Function

Lipid phosphate phosphohydrolase 1 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000067113 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Kai M, Wada I, Imai S, Sakane F, Kanoh H (Oct 1997). "Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase". J Biol Chem. 272 (39): 24572–24578. doi:10.1074/jbc.272.39.24572. PMID 9305923.
  4. 1 2 "Entrez Gene: PPAP2A phosphatidic acid phosphatase type 2A".

Further reading


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