Pauline Johnson
Born
Yorkshire, England
Alma materLiverpool University
University of Dundee
Oxford University
Salk Institute
Known forWork on lymphocyte cell surface molecules and hyaluronan
Scientific career
FieldsImmunology
InstitutionsUniversity of British Columbia

Pauline Johnson is an English immunologist and microbiologist at the University of British Columbia.[1] Her research focuses on innate and adaptive immune mechanisms — in particular, the mobility of proteins in membranes, lymphocyte cell surface molecules, T cell signalling, leukocyte adhesion, and macrophages in lung inflammation.[1]

Education

Pauline Johnson was born in Yorkshire, England. She earned a BSc in biochemistry from Liverpool University in 1980, and a Ph.D from the University of Dundee in 1983.[1][2] Her Ph.D. project was to determine the lateral and rotational mobility of membrane components measured by fluorescence recovery after photobleaching and fluorescence depletion recovery. [3]

She was a post-doctoral fellow at the Salk Institute in California, US under the supervision of Ian Trowbridge and at the MRC Cellular Immunology Unit at the University of Oxford, U.K. under the supervision of Alan F. Williams[4] before joining the faculty at the University of British Columbia in 1991.[2]

Career and research

Johnson helped to establish the function of CD45 as a critical protein tyrosine phosphatase in T cell activation [5] and defined the mechanisms regulating the interactions of the cell adhesion molecule CD44 with the matrix component, hyaluronan.[6]

Her research in 2020 uses mouse models of lung disease to study the function of macrophages and the cell matrix in infection, inflammation, and cancer.[1]

She held an MRC Scientist Award and was Co-Director of the Infection, Inflammation and Immunity Research Group at the Life Science Institute at UBC (2003-2009).[2] She has served multiple times on the CIHR Immunology and Transplantation panel, including as Scientific Officer, as well as on other national and international review panels. She is a member of the CIHR III Institute Advisory Board (III institute = Inflammation, infection and immunity CIHR Institute).[2]

Awards

  • MRC Scientist Award, MRC of Canada, 1999-2004
  • Women in Science Award for Community Leadership and Scientific Excellence, Minerva Foundation for B.C. Women, 2013[7]

Publications

  • Johnson, P. & Garland, P. B. (1981). "Depolarisation of fluorescence depletion. A microscopic method for measuring rotational diffusion of membrane proteins on the surface of a single cell". FEBS Lett. 132 (2): 252–256. doi:10.1016/0014-5793(81)81172-6. PMID 6170530.{{cite journal}}: CS1 maint: multiple names: authors list (link)

References

  1. 1 2 3 4 "Pauline Johnson | Life Sciences Institute". lsi.ubc.ca.
  2. 1 2 3 4 "III Institute Advisory Board Members – Biographies - CIHR". 12 December 2017.
  3. ↑ Johnson, P. & Garland, P. B. (1981). "Depolarisation of fluorescence depletion. A microscopic method for measuring rotational diffusion of membrane proteins on the surface of a single cell". FEBS Lett. 132 (2): 252–256. doi:10.1016/0014-5793(81)81172-6. PMID 6170530.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ↑ Crumpton, M. J. (2004). "Alan Frederick Williams. 25 May 1945 – 9 April 1992 | Semantic Scholar". Biographical Memoirs of Fellows of the Royal Society. 50: 351–366. doi:10.1098/rsbm.2004.0023. PMID 15770768. S2CID 35108488.
  5. ↑ Johnson, P., Ostergaard, H. L., Wasden, C. & Trowbridge, I. S. (1992). "Mutational analysis of CD45, a leukocyte specific tyrosine phosphatase". Journal of Biological Chemistry. 267 (12): 8035–8041. doi:10.1016/S0021-9258(18)42404-0. PMID 1314815.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ↑ Maiti, A., Maki, G. & Johnson P. (1998). "TNF-α induction of CD44-mediated leukocyte adhesion by sulfation". Science. 282 (5390): 941–943. Bibcode:1998Sci...282..941M. doi:10.1126/science.282.5390.941. PMID 9794764.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ↑ "Announcing the Honourees for Women In™ Science". Minerva BC. 12 November 2013.
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