PGA3
Identifiers
AliasesPGA3, pepsinogen 3, group I (pepsinogen A), pepsinogen A3
External IDsHomoloGene: 68135 GeneCards: PGA3
Orthologs
SpeciesHumanMouse
Entrez

643834

n/a

Ensembl

ENSG00000229859

n/a

UniProt

P0DJD8

n/a

RefSeq (mRNA)

NM_001079807

n/a

RefSeq (protein)

NP_001073275

n/a

Location (UCSC)Chr 11: 61.2 – 61.21 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. [3]

Function

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000229859 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: Pepsinogen 3, group I (pepsinogen A)". Retrieved 2017-08-25.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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