Peptitergents (a portmanteau of peptide and detergent) are synthetic peptides designed to be lipophilic on one side and hydrophilic on the other upon folding to an α-helical conformation and were designed to solubilize integral membrane proteins in aqueous solution.[1] They can be considered a sub-class of amphipols and are based on earlier fundamental explorations of amphiphilic secondary structures[2]

See also

References

  1. ↑ Schafmeister, CE; Miercke, LJ; Stroud, RM (29 October 1993). "Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins". Science. 262 (5134): 734–8. doi:10.1126/science.8235592. PMID 8235592.
  2. ↑ Kaiser, ET; Kézdy, FJ (20 January 1984). "Amphiphilic secondary structure: design of peptide hormones". Science. 223 (4633): 249–55. Bibcode:1984Sci...223..249K. doi:10.1126/science.6322295. PMID 6322295.


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