Pharmahuasca is a pharmaceutical version of the entheogenic brew ayahuasca. Traditional ayahuasca is made by brewing the MAOI-containing Banisteriopsis caapi vine with a DMT-containing plant, such as Psychotria viridis. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant.
N,N-DMT and harmaline or harmine are typically used as components of pharmahuasca. As a rule, the fewer the β-carbolines, the less nausea; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and the capsules containing DMT are taken 15 to 20 minutes later. A synthetic MAOI can be used in place of harmaline and harmine, although caution must be taken when choosing an MAOI.[1] The use of moclobemide, a reversible inhibitor of monoamine oxidase-A (RIMA), has been recorded and is safer than older irreversible MAOIs (such as isocarboxazid) due to its significantly shorter and more selective effects (although it still exhibits a wide range of dangerous drug-drug interactions).[2][3]
See also
External links
- Erowid: Ayahuasca
- A General Introduction to Ayahuasca Archived 2015-10-13 at the Wayback Machine
References
- ↑ Ott J. Ayahuasca Analogues: Pangaen Entheogens. Natural Products Co.. 1994. 34
- ↑ Kaasik, Helle; Souza, Rita C. Z.; Zandonadi, Flávia S.; Tófoli, Luís Fernando; Sussulini, Alessandra (2020-09-08). "Chemical Composition of Traditional and Analog Ayahuasca". Journal of Psychoactive Drugs. 53 (1): 65–75. doi:10.1080/02791072.2020.1815911. ISSN 2159-9777. PMID 32896230. S2CID 221543172.
- ↑ Ruffell, Simon; Netzband, Nige; Bird, Catherine; Young, Allan H.; Juruena, Mario F.; Ruffell, Simon; Netzband, Nige; Bird, Catherine; Young, Allan H.; Juruena, Mario F. (2020-07-03). "The pharmacological interaction of compounds in ayahuasca: a systematic review". Brazilian Journal of Psychiatry. 42 (6): 646–656. doi:10.1590/1516-4446-2020-0884. ISSN 1516-4446. PMC 7678905. PMID 32638916.