Phosphinothricin acetyltransferase
Identifiers
EC no.2.3.1.183
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Phosphinothricin acetyltransferase (EC 2.3.1.183, PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + phosphinothricin CoA + N-acetylphosphinothricin

The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.

Reaction.

References

  1. Botterman J, Gosselé V, Thoen C, Lauwereys M (June 1991). "Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins". Gene. 102 (1): 33–7. doi:10.1016/0378-1119(91)90534-i. PMID 1864506.
  2. Droge-Laser W, Siemeling U, Puhler A, Broer I (May 1994). "The Metabolites of the Herbicide L-Phosphinothricin (Glufosinate) (Identification, Stability, and Mobility in Transgenic, Herbicide-Resistant, and Untransformed Plants)". Plant Physiology. 105 (1): 159–166. doi:10.1104/pp.105.1.159. PMC 159341. PMID 12232195.
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