Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage.[1]

References

  1. ↑ Wilusz CJ, Wilusz J (2008). "New ways to meet your (3') end oligouridylation as a step on the path to destruction". Genes Dev. 22 (1): 1–7. doi:10.1101/gad.1634508. PMC 2731568. PMID 18172159.


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