The Prati criteria are a revision to the clinical definition of normal serum alanine aminotransferase (ALT) which was published in the Annals of Internal Medicine in 2002.[1] Daniele Prati and colleagues identified that, in the original research which developed guidelines for normal ranges of ALT, the cohort included subjects with subclinical disease such as non-alcoholic fatty liver disease. This led to ranges of 40 U/L in men and 30 U/L in women. This marker had low sensitivity and high specificity due to classification of individuals with subclinical disease counted as healthy controls. Revised model criteria led to a healthy range of 19 U/L in women and 30 U/L in men. This led to a 21.3% increase in sensitivity for an 8.9% decrease in specificity.

References

  1. ↑ Prati, Daniele; Taioli, Emanuela; Zanella, Alberto; Della Torre, Emanuela; Butelli, Sonia; Del Vecchio, Emanuela; Vianello, Luciana; Zanuso, Francesco; Mozzi, Fulvio; Milani, Silvano; Conte, Dario; Colombo, Massimo; Sirchia, Girolamo (2002). "Updated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels". Ann Intern Med. 137 (1): 1–9. doi:10.7326/0003-4819-137-1-200207020-00006. PMID 12093239. S2CID 21089296.


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