Princess Imoukhuede
Born
Princess Izevbua Imoukhuede

1980 (age 43–44)
Alma materMassachusetts Institute of Technology
California Institute of Technology
AwardsNational Science Foundation CAREER Award (2017)
Scientific career
FieldsSystems Biology
Vascular Biology
Cellular and Molecular Bioengineering
Regenerative Medicine[1]
InstitutionsWashington University in St. Louis
Johns Hopkins University
University of Illinois at Urbana–Champaign
ThesisVisualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1 (2008)
Doctoral advisorHenry A. Lester[2]
Websiteimoukhuedelab.wustl.edu

Princess Imoukhuede (born 1980) is an American chemical engineer who is a Professor in Bioengineering at the University of Washington.[3] Before 2022, she was an associate professor at the Washington University in St. Louis. She was awarded the 2018 Illinois Mathematics and Science Academy Distinguished Leadership Award and the 2018 Nano Research Young Innovators Award in Nanobiotechnology. Her first name is 'Princess' and she holds no royal title or position in any capacity.

Early life and education

Imoukhuede grew up in Matteson, Illinois.[4] She was involved with track and field as a child, and competed in shot put from the age of eight. By the time she was in eighth grade she had become interested in science, and her parents gave her a chemistry set to play with at home.[5] Imoukhuede attended the Illinois Mathematics and Science Academy.[5] Imoukhuede was an undergraduate student in biomedical engineering at Massachusetts Institute of Technology (MIT), where she performed undergraduate research under the supervision of Robert S. Langer on the incorporation of adenoviruses in a liposome-based gene therapy system. In her freshman year she was honoured at the Eastern College Athletic Conference, and was the first woman from MIT to qualify for the National Collegiate Athletic Association. Whilst at MIT, Imoukhuede took part in athletics, serving as captain of the varsity track and field team. Imoukhuede was described by Roger Crosley, then MIT Director of Sport, as "the best weight thrower we ever had in track and field". After earning her bachelor's degree, Imoukhuede moved to the California Institute of Technology, where she worked with Henry A. Lester on the structure of the GABA transporter and Förster resonance energy transfer.[2] She was the first African American woman to receive a PhD in bioengineering from Caltech.[3]

Research and career

Imoukhuede was a postdoctoral scholar at Johns Hopkins University, where she specialised in biomedical engineering in the laboratory of Aleksander Popel.[5] She started working on the vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in ischemia and cancer. After completing her postdoctoral research, Imoukhuede joined the University of Illinois at Urbana–Champaign.[6]

Imoukhuede studies the mechanisms that regulate angiogenic signalling, including tyrosine kinase receptors, VEGF receptors and platelet-derived growth factor receptors. In 2019 Imoukhuede and Sarah K. England partnered to improve the efficacy and safety of oxytocin during labour.[7] Imoukhuede is developing a computational model that could be used to predict the function of oxytocin receptor function.[7]

Awards and honours

Selected publications

Her publications[1] include:

  • Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits[10]
  • Quantification and cell-to-cell variation of vascular endothelial growth factor receptors[11]
  • Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies[12]
  • Sex differences in cancer mechanisms[13]

References

  1. 1 2 Princess Imoukhuede publications indexed by Google Scholar
  2. 1 2 Imoukhuede, Princess Izevbua (2008). Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1 (PhD thesis). Pasadena, California: California Institute of Technology. OCLC 437168185.
  3. 1 2 "Meet Princess Imoukhuede | UW Bioengineering". 2022-02-18. Retrieved 2023-10-17.
  4. ↑ "Princess Imoukhuede". MIT Spectrum. Retrieved 2020-10-21.
  5. 1 2 3 "410: Dr. Princess Imoukhuede: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation". People Behind the Science Podcast. 2017-08-14. Retrieved 2020-10-21.
  6. ↑ "Imoukhuede Systems Biology Laboratory". Retrieved 2020-10-22.
  7. 1 2 "Imoukhuede teams with England on $2.4M NIH grant". engineering.wustl.edu. 11 September 2019. Retrieved 2020-10-21.
  8. ↑ "NSF Award Search: Award#1653925 - CAREER: qBio+cBio=sBio; Identifying the role of cross-family signaling in angiogenesis". nsf.gov. Retrieved 2020-10-21.
  9. ↑ Napier, Douglas H. (1992). "Workbook of test cases for vapor cloud source dispersion models, By Steven R. Hanna and David Strimaitis for the Centre for Chemical Process Safety of the American Institute of Chemical Engineers 1989, 122 + xv pages". The Canadian Journal of Chemical Engineering. New York: American Institute of chemical Engineers. 70 (4): 831. doi:10.1002/cjce.5450700433. ISBN 0-8169-0455-3. ISSN 0008-4034.
  10. ↑ Drenan, Ryan M.; Nashmi, Raad; Imoukhuede, Princess; Just, Herwig; McKinney, Sheri; Lester, Henry A. (2008). "Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits". Molecular Pharmacology. 73 (1): 27–41. doi:10.1124/mol.107.039180. ISSN 0026-895X. PMID 17932221. S2CID 14327818.
  11. ↑ Imoukhuede, P.I.; Popel, Aleksander S. (2011). "Quantification and cell-to-cell variation of vascular endothelial growth factor receptors". Experimental Cell Research. 317 (7): 955–965. doi:10.1016/j.yexcr.2010.12.014. ISSN 0014-4827. PMC 3073416. PMID 21185287.
  12. ↑ Finley, Stacey D; Engel-Stefanini, Marianne O; Imoukhuede, PI; Popel, Aleksander S (2011). "Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies". BMC Systems Biology. 5 (1): 193. doi:10.1186/1752-0509-5-193. ISSN 1752-0509. PMC 3229549. PMID 22104283.
  13. ↑ Rubin, Joshua B; Lagas, Joseph S; Broestl, Lauren; Sponagel, Jasmin; Rockwell, Nathan; Rhee, Gina; Rosen, Sarah F; Chen, Si; Klein, Robyn S; Imoukhuede, Princess; Luo, Jingqin (2020). "Sex differences in cancer mechanisms". Biology of Sex Differences. 11 (1): 17. doi:10.1186/s13293-020-00291-x. ISSN 2042-6410. PMC 7161126. PMID 32295632.
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