Proquazone
Clinical data
ATC code
Identifiers
  • 1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.079
Chemical and physical data
FormulaC18H18N2O
Molar mass278.355 g·mol−1
3D model (JSmol)
  • CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
  • InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 ☒N
  • Key:JTIGKVIOEQASGT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Proquazone is a nonsteroidal anti-inflammatory drug, known as an NSAID.[1]

Uses

Proquazone is used to treat rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.[1] It has been trialed for use as pain relief for tension headaches.[2]

The recommended adult dose is around 450mg.[1]

Side Effects

Often, use of Proquazone is associated with diarrhea (up to 30% of the time).[1]

References

  1. 1 2 3 4 Clissold SP, Beresford R (May 1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states". Drugs. 33 (5): 478–502. doi:10.2165/00003495-198733050-00004. PMID 3297621. S2CID 195697106.
  2. ↑ DiSerio FJ, Friedman AP, Parno J, Singer JM (May 1985). "Proquazone for tension headache--a multicenter trial". Headache. 25 (3): 127–133. doi:10.1111/j.1526-4610.1985.hed2503127.x. PMID 3891682. S2CID 9283866.
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