| RBM6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RBM6, 3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16, RNA binding motif protein 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606886 MGI: 1338037 HomoloGene: 31336 GeneCards: RBM6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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RNA-binding protein 6 is a protein that in humans is encoded by the RBM6 gene.[5][6] RBM6 orthologs[7] have been identified in all mammals for which complete genome data are available.
RBM6 splicing factor interacts with the DNA repair protein RAD51, and is also recruited to DNA double-strand breaks where it promotes homologous recombinational repair.[8]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000004534 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032582 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3". Eur J Hum Genet. 7 (4): 478–86. doi:10.1038/sj.ejhg.5200334. PMID 10352938.
- ↑ "Entrez Gene: RBM6 RNA binding motif protein 6".
- ↑ "OrthoMaM phylogenetic marker: RBM6 coding sequence". Archived from the original on 2016-03-03. Retrieved 2009-12-09.
- ↑ Awwad SW, Darawshe MM, Machour FE, Arman I, Ayoub N. Recruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair. Mol Cell Biol. 2023;43(3):130-142. doi: 10.1080/10985549.2023.2187105. PMID: 36941773; PMCID: PMC10038030
Further reading
- Güre AO, Altorki NK, Stockert E, et al. (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41. PMID 9500467.
{{cite journal}}: CS1 maint: overridden setting (link) - Drabkin HA, West JD, Hotfilder M, et al. (1999). "DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC". Oncogene. 18 (16): 2589–97. doi:10.1038/sj.onc.1202601. PMID 10353602. S2CID 24925641.
{{cite journal}}: CS1 maint: overridden setting (link) - Timmer T, Terpstra P, van den Berg A, et al. (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics. 60 (2): 238–40. doi:10.1006/geno.1999.5878. PMID 10486216.
{{cite journal}}: CS1 maint: overridden setting (link) - Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: CS1 maint: overridden setting (link) - Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: CS1 maint: overridden setting (link) - Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
{{cite journal}}: CS1 maint: overridden setting (link) - Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
{{cite journal}}: CS1 maint: overridden setting (link) - Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
{{cite journal}}: CS1 maint: overridden setting (link) - Gu TL, Mercher T, Tyner JW, et al. (2007). "A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia". Blood. 110 (1): 323–33. doi:10.1182/blood-2006-10-052282. PMC 1896120. PMID 17360941.
{{cite journal}}: CS1 maint: overridden setting (link) - Wang K, Ubriaco G, Sutherland LC (2007). "RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours". BMC Genomics. 8: 348. doi:10.1186/1471-2164-8-348. PMC 2174484. PMID 17908320.
External links
- RBM6 human gene location in the UCSC Genome Browser.
- RBM6 human gene details in the UCSC Genome Browser.
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