RGS6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS6, GAP, regulator of G-protein signaling 6, regulator of G protein signaling 6, HA117, S914
External IDsOMIM: 603894 MGI: 1354730 HomoloGene: 68385 GeneCards: RGS6
Orthologs
SpeciesHumanMouse
Entrez

9628

50779

Ensembl

ENSG00000182732

ENSMUSG00000021219

UniProt

P49758

Q9Z2H2

RefSeq (mRNA)

NM_001282061
NM_015812
NM_001310478

RefSeq (protein)

NP_001268990
NP_001297407
NP_056627

Location (UCSC)Chr 14: 71.93 – 72.57 MbChr 12: 82.64 – 83.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.[5][6][7]

Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM][7]

Interactions

RGS6 has been shown to interact with STMN2[8] and DMAP1.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182732 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021219 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". Journal of Human Genetics. 44 (2): 138–40. doi:10.1007/s100380050129. PMID 10083744.
  6. 1 2 Liu Z, Fisher RA (April 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". The Journal of Biological Chemistry. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.
  7. 1 2 "Entrez Gene: RGS6 regulator of G-protein signalling 6".
  8. Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.

Further reading


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