Rob Klose
Rob Klose in 2016
Born (1977-12-28) December 28, 1977
Alma mater
Awards
Websitehttps://kloselab.co.uk/ Edit this on Wikidata
Academic career
Institutions
Known forResearch on chromatin-based and epigenetic mechanisms
Scientific career
ThesisBiochemical analysis of MeCP2 (2005)
Doctoral advisorAdrian Bird

Rob Klose (born December 28, 1977) is a Canadian researcher and Professor of Genetics at the Department of Biochemistry, University of Oxford.[1][2][3] His research investigates how chromatin-based and epigenetic mechanisms contribute to the ways in which gene expression is regulated.[4][5][6]

Education

Klose was an undergraduate student at the University of Waterloo in Ontario, Canada, where he graduated with Dean's Honors in Biology. He was a postgraduate student supervised by Adrian Bird at the Wellcome Centre for Cell Biology at the University of Edinburgh, Scotland, where he studied the methyl CpG binding protein MeCP2, part of the DNA methylation system, which is associated with Rett syndrome.[7] He obtained his Doctor of Philosophy in 2005.[8]

Career and research

Klose spent two years as a postdoctoral researcher in the laboratory of Yi Zhang, who was based at the University of North Carolina at Chapel Hill, identifying a novel family of histone lysine demethylase enzymes.[9][10][11] He then moved to the University of Oxford where, in 2008, he established himself as a Principal Investigator at the Department of Biochemistry at Oxford supported by a Wellcome Trust career development fellowship. Five years after this, he secured a Wellcome Trust senior research fellowship. Since then, he has been a Monsanto senior research fellow, a post associated with Exeter College, Oxford, and in 2014 was appointed as professor of cell and molecular biology. In 2017 he was appointed Professor of Genetics, University of Oxford, a chair held at the department of biochemistry and associated with a fellowship at Keble College, Oxford.

Klose's work throughout his career has sought to explain how, during development, cell types with the same DNA use chromatin-based and epigenetic mechanisms to restrict gene expression to the correct complement of genes in a stable and heritable way. In particular, he has focused on understanding how DNA encoded regulatory elements in vertebrates, called CpG islands, help to achieve appropriately controlled gene usage.

Awards and honours

Klose was awarded a European Molecular Biology Organization (EMBO) young investigator programme fellowship in 2010[12] and was awarded a Lister Institute of Preventive Medicine Research prize in 2011.[13] In recognition of his achievements as an early career stage scientist, he was awarded the Francis Crick Lecture by the Royal Society in 2015.[14] He was elected EMBO Member in 2021.[15]

References

  1. ↑ Rob Klose publications from Europe PubMed Central
  2. ↑ Rob Klose publications indexed by Google Scholar
  3. ↑ Klose, Rob. "Professor Rob Klose". Department of Biochemistry, University of Oxford. Retrieved 6 November 2017.
  4. ↑ Klose, Rob (2010). "CpG islands recruit a histone H3 lysine 36 demethylase". Mol. Cell. 38 (2): 179–90. doi:10.1016/j.molcel.2010.04.009. PMC 3098377. PMID 20417597.
  5. ↑ Klose, Rob (2013). "ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection". Biochem Soc Trans. 41 (3): 727–40. doi:10.1042/BST20130028. PMC 3685328. PMID 23697932.
  6. ↑ Klose, Rob (2014). "Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation". Cell. 157 (6): 1445–59. doi:10.1016/j.cell.2014.05.004. PMC 4048464. PMID 24856970.
  7. ↑ Klose, Rob (2005). "DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG". Mol. Cell. 19 (5): 667–78. doi:10.1016/j.molcel.2005.07.021. PMID 16137622.
  8. ↑ Klose, Rob (2005). Biochemical analysis of MeCP2. ed.ac.uk (PhD thesis). University of Edinburgh. hdl:1842/10997. EThOS uk.bl.ethos.653493.
  9. ↑ Klose, Rob (2006). "The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36". Nature. 442 (7100): 312–6. Bibcode:2006Natur.442..312K. doi:10.1038/nature04853. PMID 16732292. S2CID 4399312.
  10. ↑ Klose, Rob (2007). "The retinoblastoma binding protein RBP2 is an H3K4 demethylase". Cell. 128 (5): 889–900. doi:10.1016/j.cell.2007.02.013. PMID 17320163.
  11. ↑ Klose, Rob (2007). "Regulation of histone methylation by demethylimination and demethylation". Nat Rev Mol Cell Biol. 8 (4): 307–18. doi:10.1038/nrm2143. PMID 17342184. S2CID 2616900. Closed access icon
  12. ↑ "Twenty-one group leaders join network of EMBO Young Investigators". EMBO Press release 2010. Retrieved 7 November 2017.
  13. ↑ "Lister Institute Current Prize Fellows". Lister Institute. Retrieved 7 November 2017.
  14. ↑ "Gene regulation and the epigenome, Prize lecture on 2 December 2015". Royal Society. Retrieved 7 November 2017.
  15. ↑ "Find people in the EMBO Communities".
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