SAP130
Identifiers
AliasesSAP130, Sin3A associated protein 130
External IDsOMIM: 609697 MGI: 1919782 HomoloGene: 11577 GeneCards: SAP130
Orthologs
SpeciesHumanMouse
Entrez

79595

269003

Ensembl

ENSG00000136715

ENSMUSG00000024260

UniProt

Q9H0E3

Q8BIH0

RefSeq (mRNA)

NM_172965
NM_001357554
NM_001357555

RefSeq (protein)

NP_766553
NP_001344483
NP_001344484

Location (UCSC)Chr 2: 127.94 – 128.03 MbChr 18: 31.77 – 31.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.[5][6][7]

Function

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM][7]

Interactions

SAP130 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136715 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024260 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. 1 2 Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
  7. 1 2 "Entrez Gene: SAP130 Sin3A-associated protein, 130kDa".
  8. 1 2 3 Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochemistry. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.
  9. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

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