SAP18

SAP18
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2HDE
Identifiers
Aliases	SAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
External IDs	OMIM: 602949 MGI: 3704317 HomoloGene: 4289 GeneCards: SAP18
Gene location (Human)
Chr.	Chromosome 13 (human)
End	21,149,084 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	96,552,762 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; right ventricle; ; tendon; ; corpus epididymis; ; Achilles tendon; ; caput epididymis; ; bronchial epithelial cell; ; biceps brachii; ; cavity of mouth; ; spongy bone;
	Top expressed in
	yolk sac; ; neural tube; ; stomach; ; lens; ; proximal tubule; ; limb; ; ileum; ; quadriceps femoris muscle; ; lip; ; jejunum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; protein binding; histone deacetylase activity; RNA binding;
Cellular component	histone deacetylase complex; nuclear speck; exon-exon junction complex; nucleoplasm; ASAP complex; nucleus; cytoplasm; cytosol; nuclear body;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; transcription, DNA-templated; negative regulation of mRNA splicing, via spliceosome; RNA splicing; positive regulation of apoptotic process; negative regulation of nucleic acid-templated transcription; histone deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	10284
	100041953
	ENSG00000150459
	ENSMUSG00000061104
	O00422
	n/a
	NM_005870; NM_001366643
	NM_001142441
	NP_005861; NP_001353572
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.^[5]^[6]

Function

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.^[6] Additionally, SAP18s splice variants are implicated in apoptotic cycles.^[7]

Interactions

SAP18 has been shown to interact with

POLE2,^[8]^[9] and
RGS10.^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000150459 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061104 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
1 2 "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa".
↑ Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B (March 2012). "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators". Molecular and Cellular Biology. 32 (5): 954–67. doi:10.1128/MCB.06130-11. PMC 3295189. PMID 22203037.
↑ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (March 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
↑ Cheng SY, Bishop JM (April 2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5442–7. Bibcode:2002PNAS...99.5442C. doi:10.1073/pnas.082096999. PMC 122788. PMID 11960000.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

SAP18 human gene location in the UCSC Genome Browser.
SAP18 human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000150459 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061104 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9150135-5] Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.

[entrez-6] 1 2 "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa".

[pmid22203037-7] Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B (March 2012). "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators". Molecular and Cellular Biology. 32 (5): 954–67. doi:10.1128/MCB.06130-11. PMC 3295189. PMID 22203037.

[pmid11872158-8] Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (March 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

[pmid11960000-9] Cheng SY, Bishop JM (April 2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5442–7. Bibcode:2002PNAS...99.5442C. doi:10.1073/pnas.082096999. PMC 122788. PMID 11960000.

[pmid17353931-10] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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Function

Interactions

References

Further reading

External links