SEC61B

SEC61B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WWB, 4CG6
Identifiers
Aliases	SEC61B, Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDs	OMIM: 609214 MGI: 1913462 HomoloGene: 38229 GeneCards: SEC61B
Gene location (Human)
Chr.	Chromosome 9 (human)
End	99,230,615 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	47,483,242 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; body of pancreas; ; oocyte; ; corpus epididymis; ; pylorus; ; anterior pituitary; ; trachea; ; right lobe of liver; ; cardia; ; canal of the cervix;
	Top expressed in
	parotid gland; ; seminal vesicula; ; submandibular gland; ; islet of Langerhans; ; molar; ; maxillary prominence; ; somite; ; lacrimal gland; ; crypt of lieberkuhn of small intestine; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	epidermal growth factor binding; protein binding; RNA binding; protein-transporting ATPase activity;
Cellular component	integral component of membrane; cytosol; membrane; Sec61 translocon complex; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum Sec complex;
Biological process	retrograde protein transport, ER to cytosol; IRE1-mediated unfolded protein response; ubiquitin-dependent ERAD pathway; protein transport; intracellular protein transport; SRP-dependent cotranslational protein targeting to membrane, translocation; posttranslational protein targeting to membrane, translocation; transport; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	10952
	66212
	ENSG00000106803
	ENSMUSG00000053317
	P60468
	Q9CQS8
	NM_006808
	NM_024171
	NP_006799
	NP_077133
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.^[5]^[6]^[7]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106803 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053317 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
↑ Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
1 2 "Entrez Gene: SEC61B Sec61 beta subunit".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469. S2CID 6276718.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex". Biochem. J. 331 (Pt 1): 161–7. doi:10.1042/bj3310161. PMC 1219334. PMID 9512475.
Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". J. Biol. Chem. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
Kalies KU, Rapoport TA, Hartmann E (1998). "The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation". J. Cell Biol. 141 (4): 887–94. doi:10.1083/jcb.141.4.887. PMC 2132780. PMID 9585408.
Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary". J. Biol. Chem. 273 (45): 29873–8. doi:10.1074/jbc.273.45.29873. PMID 9792704.
Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation". J. Cell Biol. 147 (6): 1195–204. doi:10.1083/jcb.147.6.1195. PMC 2168098. PMID 10601334.
Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID 10799540.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Besemer J, Harant H, Wang S, et al. (2005). "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1". Nature. 436 (7048): 290–3. Bibcode:2005Natur.436..290B. doi:10.1038/nature03670. PMID 16015337. S2CID 4431610.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Liao HJ, Carpenter G (2007). "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression". Mol. Biol. Cell. 18 (3): 1064–72. doi:10.1091/mbc.E06-09-0802. PMC 1805100. PMID 17215517.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106803 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053317 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8107851-5] Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.

[pmid10212142-6] Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.

[entrez-7] 1 2 "Entrez Gene: SEC61B Sec61 beta subunit".

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[4]

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[6]

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References

Further reading