SEPT4
Identifiers
AliasesSEPT4, ARTS, BRADEION, CE5B3, H5, MART, PNUTL2, SEP4, hCDCREL-2, hucep-7, septin 4, Sept4
External IDsOMIM: 603696 MGI: 1270156 HomoloGene: 6107 GeneCards: SEPT4
Orthologs
SpeciesHumanMouse
Entrez

5414

18952

Ensembl

ENSG00000108387

ENSMUSG00000020486

UniProt

O43236

P28661

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 17: 58.52 – 58.54 MbChr 11: 87.46 – 87.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.[5][6]

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108387 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020486 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L (January 1999). "Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene". Genomics. 55 (1): 122–5. doi:10.1006/geno.1998.5612. PMID 9889007.
  6. 1 2 "Entrez Gene: SEPT4 septin 4".

Further reading


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