SEPTIN7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEPTIN7, CDC10, CDC3, NBLA02942, SEPT7A, septin 7, SEPT7
External IDsOMIM: 603151 MGI: 1335094 HomoloGene: 1354 GeneCards: SEPTIN7
Orthologs
SpeciesHumanMouse
Entrez

989

235072

Ensembl

ENSG00000122545

ENSMUSG00000001833

UniProt

Q16181

O55131

RefSeq (mRNA)

NM_001011553
NM_001242956
NM_001788
NM_001363715
NM_001375299

NM_001205367
NM_009859
NM_001359736
NM_001359737
NM_001359738

RefSeq (protein)

NP_001011553
NP_001229885
NP_001779
NP_001350644
NP_001362228

NP_001192296
NP_033989
NP_001346665
NP_001346666
NP_001346667

Location (UCSC)Chr 7: 35.8 – 35.91 MbChr 9: 25.16 – 25.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.[5][6]

Function

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.[6]

Interactions

SEPT7 has been shown to interact with SEPT2[7][8] and SEPT9.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000122545 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001833 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nakatsuru S, Sudo K, Nakamura Y (July 1994). "Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae". Biochemical and Biophysical Research Communications. 202 (1): 82–7. doi:10.1006/bbrc.1994.1896. PMID 8037772.
  6. 1 2 "Entrez Gene: SEPT7 septin 7".
  7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. 1 2 Surka MC, Tsang CW, Trimble WS (October 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.

Further reading


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