SESN3
Identifiers
AliasesSESN3, SEST3, sestrin 3
External IDsOMIM: 607768 MGI: 1922997 HomoloGene: 14386 GeneCards: SESN3
Orthologs
SpeciesHumanMouse
Entrez

143686

75747

Ensembl

ENSG00000149212

ENSMUSG00000032009

UniProt

P58005

Q9CYP7

RefSeq (mRNA)

NM_001271594
NM_144665

NM_030261

RefSeq (protein)

NP_001258523
NP_653266

NP_084537

Location (UCSC)Chr 11: 95.17 – 95.23 MbChr 9: 14.19 – 14.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sestrin 3 is a protein that in humans is encoded by the SESN3 gene. [5]

Function

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149212 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032009 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Sestrin 3". Retrieved 2017-08-05.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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