Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[1][2][3] SGTA orthologs[4] have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif.[5] STGA was discovered just 15 years ago.

SGTA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSGTA, SGT, alphaSGT, hSGT, small glutamine rich tetratricopeptide repeat containing alpha, small glutamine rich tetratricopeptide repeat co-chaperone alpha, SGT1, Vpu
External IDsOMIM: 603419 MGI: 1098703 HomoloGene: 31122 GeneCards: SGTA
Orthologs
SpeciesHumanMouse
Entrez

6449

52551

Ensembl

ENSG00000104969

ENSMUSG00000004937

UniProt

O43765

Q8BJU0

RefSeq (mRNA)

NM_003021

NM_024499
NM_001358549
NM_001358550

RefSeq (protein)

NP_003012

NP_078775
NP_001345478
NP_001345479

Location (UCSC)Chr 19: 2.75 – 2.78 MbChr 10: 80.88 – 80.9 Mb
PubMed search[8][9]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat (TRP)-containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1.[10]

The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[3]

Overview of main functions:[5]

  • hormone signaling
  • viral assembly and release
  • cell cycle and apoptosis
  • intracellular compartmentalization
  • neuronal synaptic transmission
  • post-translational transport and modification of proteins.

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (STGA) acts as a co-chaperone and regulator of androgen and growth hormone receptor signaling.[5] The protein also mediates targets to the endoplasmic reticulum

Interactions

SGTA has been shown to interact with Growth hormone receptor.[2]

Interacting Proteins for the SGTA Gene:[10]

Associated Diseases[5]

  • Prostate, ovary, liver, and esophagus cancer
  • Hormone-related polycystic ovary syndrome
  • Amyloid-related Alzheimer's
  • Prion Diseases

References

  1. Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C (August 1998). "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans". Genomics. 52 (1): 90–94. doi:10.1006/geno.1998.5385. PMID 9740675.
  2. 1 2 Schantl JA, Roza M, De Jong AP, Strous GJ (August 2003). "Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor". The Biochemical Journal. 373 (Pt 3): 855–863. doi:10.1042/BJ20021591. PMC 1223544. PMID 12735788.
  3. 1 2 "Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha".
  4. "OrthoMaM phylogenetic marker: SGTA coding sequence". Archived from the original on 2016-03-03. Retrieved 2010-02-17.
  5. 1 2 3 4 Philp LK, Day TK, Butler MS, Laven-Law G, Jindal S, Hickey TE, et al. (June 2016). "Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice". Scientific Reports. 6 (1): 28950. doi:10.1038/srep28950. PMC 4928056. PMID 27358191.
  6. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104969 - Ensembl, May 2017
  7. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004937 - Ensembl, May 2017
  8. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  9. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  10. 1 2 "STGA". GeneCards The Human Gene Database. Retrieved 2023-11-28.

Further reading

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